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Antibodies against Trypanosoma cruzi accompanying the antitumoral action of lysed epimastigotes in vivo

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Abstract

Three sources of antibodies against T. cruzi have been discovered in mouse blood: (1) spontaneous origin; (2) implantation of adenocarcinoma; (3) injection of lysed epimastigote form of trypanosome. In all of these cases, they represent the assortment of antibodies to the genetically different clones of T. cruzi. Their presence in mouse blood correlates with the inhibition of tumor growth. There are significant similarities between antibodies induced by lysed T. cruzi and induced by tumor implantation, the main of which is prevalence of homology to the same clones: G, P, Sp (group DTU1), and MAS (subgroup DTU2b).

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Authors and Affiliations

  1. Department of Invertebrate Zoology, Moscow State University, Moscow, Russia

    V. D. Kallinikova, Z. Batmonch, E. G. Kravtsov, L. P. Karpenko, L. V. Pachorukova & T. A. Ogloblina

  2. Department of Microbiology, Peoples’ Friendship University of Russia, Moscow, Russia

    V. D. Kallinikova, Z. Batmonch, E. G. Kravtsov, L. P. Karpenko, L. V. Pachorukova & T. A. Ogloblina

Authors
  1. V. D. Kallinikova
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  2. Z. Batmonch
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  3. E. G. Kravtsov
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  4. L. P. Karpenko
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  5. L. V. Pachorukova
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  6. T. A. Ogloblina
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Corresponding author

Correspondence to Z. Batmonch.

Additional information

Original Russian Text © V.D. Kallinikova, Z. Batmonch, E.G. Kravtsov, L.P. Karpenko, L.V. Pachorukova, T.A. Ogloblina, 2008, published in Vestnik Moskovskogo Universiteta. Biologiya, 2008, No. 2, pp. 26–31.

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Kallinikova, V.D., Batmonch, Z., Kravtsov, E.G. et al. Antibodies against Trypanosoma cruzi accompanying the antitumoral action of lysed epimastigotes in vivo. Moscow Univ. Biol.Sci. Bull. 63, 72–76 (2008). https://doi.org/10.3103/S0096392508020053

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  • DOI: https://doi.org/10.3103/S0096392508020053

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