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Detection and Quantification of 4-Methyliniidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe2O3 Nanoparticles on Zeolite

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Abstract

Food additives generally used in carbonated drinks, such as 4-methylimidazole (4MI), caffeine (Caf ), citric acid (CA), and aspartame (Apm), were measured by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) using nanometer-sized particles of iron oxide (Fe2O3 NPs). The quantification of 4MI in Coca Cola (C-cola) was carried out. In order to improve the reproducibility of the peak intensities, Fe2O3 NPs loaded on ZSM5 zeolite were used as the matrix for quantification. By using 2-ethylimidazole (2EI) as the internal standard, the amount of 4MI in C-cola was determined to range from 88 to 65 μg/355 mL. The results agree with the published value (approx. 72 μg/355 mL). It was found that MALDI using Fe2O3 was applicable to the quantification of 4MI in C-cola.

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Acknowledgments

T. F. acknowledges a Grant-in-Aid for Scientific Research (B) (No. 15H03772) from JSPS in Japan.

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Authors and Affiliations

  1. Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, 192-0379, Japan

    Yosuke Fujii, Takafumi Akimoto & Jiawei Xu

  2. Department of Food Inspection, Zhejiang Institute for Food and Drug Control, No. 86, Lane 1, Jichang Road, Jianggan District, Hangzhou, Zhejiang, China

    Yuqi Ding

  3. Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University, 2100 Kujirai, Kawagoe, 350-8585, Japan

    Taichi Umezawa & Tatsuya Fujino

  4. Bio-Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, 350-8585, Japan

    Takashi Uchida & Tatsuya Fujino

Authors
  1. Yosuke Fujii
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  2. Yuqi Ding
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  3. Taichi Umezawa
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  4. Takafumi Akimoto
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  5. Jiawei Xu
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  6. Takashi Uchida
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  7. Tatsuya Fujino
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Correspondence to Tatsuya Fujino.

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Fujii, Y., Ding, Y., Umezawa, T. et al. Detection and Quantification of 4-Methyliniidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe2O3 Nanoparticles on Zeolite. ANAL. SCI. 34, 221–225 (2018). https://doi.org/10.2116/analsci.34.221

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  • DOI: https://doi.org/10.2116/analsci.34.221

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