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Application of a New Iridium Complex as a Chemiluminescence Reagent for the Determination of Tryptophan

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Abstract

It was found that a novel iridium complex, [(dpci)2Ir(bvbbi)](PF6) (dpci = 3,4-diphenylcinnoline, bvbbi = N,N′-bivinyester-1H,1′H-[2,2’] bibenzimidazole), with Ce(IV) in the presence of sodium sulfite can induce a great chemiluminescence (CL) emission. More importantly, a rapid and sensitive CL method for the determination of tryptophan coupled with a flow-injection analysis (FIA) technique has been developed based on the inhibition effect of the tryptophan to the CL emission of [(dpci)2Ir(bvbbi)](PF6)-Ce(IV)-SO32− system. Under the optimum conditions, the decreased CL intensity is proportional with the concentration of tryptophan in the range of 5.0 × 10−7 to 2.0 × 10−5 mol L−1, and the detection limit is 8.2 × 10−8 mol L−1 (3σ). The relative standard deviation (RSD) for 11 parallel measurements of 1.0 × 10−5 mol L−1 tryptophan is 2.7%. The proposed method has been applied successfully for the determination of tryptophan in its pharmaceutical formulations. Moreover, the possible inhibition mechanism of tryptophan on [(dpci)2Ir(bvbbi)](PF6)-Ce(IV)-SO32− CL system was briefly discussed.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Institution of Molecular Engineering and Applied Chemistry, Anhui University of Technology, 243002, Maanshan, P. R. China

    Fanghui Wu, Bihai Tong & Qianfeng Zhang

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  1. Fanghui Wu
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  2. Bihai Tong
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  3. Qianfeng Zhang
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Correspondence to Fanghui Wu or Bihai Tong.

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Wu, F., Tong, B. & Zhang, Q. Application of a New Iridium Complex as a Chemiluminescence Reagent for the Determination of Tryptophan. ANAL. SCI. 27, 529–533 (2011). https://doi.org/10.2116/analsci.27.529

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  • DOI: https://doi.org/10.2116/analsci.27.529

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