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Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

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Abstract

A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography– tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C18 column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01 – 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.

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Authors and Affiliations

  1. Department of Legal Medicine, Aichi Medical University School of Medicine, Nagakute, 480-1195, Aichi, Japan

    Tadashi Ogawa, Hideki Hattori, Kenjiro Ito, Masayo Iwai, Yoko Mizutani & Hiroshi Seno

  2. Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsuruma, 466-8550, Nagoya, Showa, Japan

    Rina Kaneko & Akira Ishii

  3. Department of Chemistry, Aichi Medical University School of Medicine, Nagakute, 480-1195, Aichi, Japan

    Tetsuya Arinobu

  4. Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Higashi, Japan

    Osamu Suzuki

Authors
  1. Tadashi Ogawa
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  2. Hideki Hattori
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  3. Rina Kaneko
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  4. Kenjiro Ito
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  5. Masayo Iwai
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  6. Yoko Mizutani
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  7. Tetsuya Arinobu
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  8. Akira Ishii
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  9. Osamu Suzuki
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  10. Hiroshi Seno
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Corresponding author

Correspondence to Tadashi Ogawa.

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Ogawa, T., Hattori, H., Kaneko, R. et al. Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. ANAL. SCI. 26, 1099–1102 (2010). https://doi.org/10.2116/analsci.26.1099

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  • DOI: https://doi.org/10.2116/analsci.26.1099

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