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Strategic Approaches for Highly Selective and Sensitive Detection of Hg2+ Ion Using Mass Sensitive Sensors

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Abstract

Here we present a quartz crystal microbalance (QCM) sensor for the highly selective and sensitive detection of Hg2+ ion, a toxic chemical species and a hazardous environmental contaminant. Hg2+ ion can be quantitatively measured based on changes in the resonance frequency of QCM following mass changes on the QCM sensor surface. The high selectivity for Hg2+ ion in this study can be obtained using a thymine-Hg2+-thymine pair, which is more stable than the adenine-thymine base pair in DNA. On the other hand, gold nanoparticles (AuNPs) and their size-enhancement techniques were used to amplify the QCM signals to increase the sensitivity for Hg2+ ion. With this strategic approach, the proposed QCM sensor can be used to quantitatively analyze Hg2+ ion with high selectivity and sensitivity. The detection limit was as low as 98.7 pM. The sensor failed to work with other metal ions at concentrations 1000-times higher than that of the Hg2+ ion. Finally, the recovery does not exceed 10% of the original value for the detection of Hg2+ ion in tap and bottled water. The results indicate acceptable accuracy and precision for practical applications.

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Acknowledgments

This work was supported by Soonchunhyang University and by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2016R1D1A3B 03934762).

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Authors and Affiliations

  1. Department of Pharmaceutical Engineering, Soonchunhyang University, 22 Soonchunhyangro, Shinchang-myeon, Asan-si, Chungcheongnam-do, 31538, Korea

    Hyeoun Ji Park & Soo Suk Lee

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  1. Hyeoun Ji Park
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  2. Soo Suk Lee
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Correspondence to Soo Suk Lee.

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Park, H.J., Lee, S.S. Strategic Approaches for Highly Selective and Sensitive Detection of Hg2+ Ion Using Mass Sensitive Sensors. ANAL. SCI. 35, 883–888 (2019). https://doi.org/10.2116/analsci.19P070

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  • DOI: https://doi.org/10.2116/analsci.19P070

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