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China Alzheimer’s Disease and Neurodegenerative Disorder Research (CANDOR) -A Prospective Cohort Study for Alzheimer’s Disease and Vascular Cognitive Impairment

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Abstract

Background

Alzheimer’s disease (AD) and vascular cognitive impairment (VCI) are the two main causes of dementia. AD and VCI share similar symptoms of cognitive decline and may be attributable to similar risk factors. Establishing a prospective cohort to compare VCI and AD would help to understand vascular risk factors related to dementia.

Objectives

China Alzheimer’s disease and Neurodegenerative Disorder Research (CANDOR) study is a prospective multicenter cohort study. It aims to study the similarities and differences between AD and post stroke cognitive impairment (PSCI) in neuroimaging changes, disease progression, and multiple omics studies.

Design

This is an ongoing study. From July 31, 2019, to August 1, 2022, we recruited 1449 participants with ages between 40 and 100 years. The cohort included three groups: AD group, PSCI group, and normal cognitive (NC) group. Data were collected in face-to-face interviews at baseline, and will be followed up every year for 4 years. The PSCI group had additional follow-ups at 3-month and 6-month after enrollment. Brain Magnetic Resonance Imaging (MRI) included high-resolution sequences for intracranial arteries. Cognitive assessments and follow-up information will be prospectively collected. Biological specimens including blood and urine at baseline were collected and tested.

Participants

The targeted sample size of PSCI group was 500, AD group with 600 and NC group with 2000. There were 1449 participants enrolled. Include 508 participants were in NC group, 387 in AD group and 554 in PSCI group.

Measurements

Demographics, clinical parameters, and medical examinations were collected and performed. Cognitive assessment was performed to assess all cognitive domains including memory, language, executive function, and orientation function.

Conclusions

The CANDOR study is a prospective cohort study. Data from this cohort provide us an opportunity to investigate the contribution of vascular factors to dementia pathogenesis.

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Availability of data and materials

SL and JS had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Acknowledgement

We would like to thank the participants and their caregivers who participated in the study.

Funding

Supported by Strategic Priority Research Program of the Chinese Academy of Sciences (XDB39000000) and Beijing Municipal Science & Technology Commission (Grant No. Z181100001518005).

Author information

Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119, South Fourth Ring West Road, Beijing, Fengtai District, 100070, People’s Republic of China

    S. Li, Y. Wang & Jiong Shi

  2. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    S. Li, Y. Wang & Jiong Shi

  3. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China

    S. Li, Y. Wang & Jiong Shi

  4. Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, China

    H. Dong & M. Dong

  5. Department of Neurology, Hebei Yanda Hospital, Sanhe, Hebei Province, China

    S. Wang

  6. Department of Neurology, The First Affiliated Hospital of USTC, Anhui Provincial Hospital, Hefei, China

    X. Lv

  7. Department of Neurology, First Hospital of Hebei Medical University, Shijiazhuang, China

    S. Tian

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Contributions

SL and JS designed the study. HD, YW, SW, XL, MD, ST collected data. SL, HD, YW and JS analyzed data. YW and SL created the tables. SL, YW and JS did the scientific literature search. SL, HD, YW, and JS wrote and all authors edited the report. All authors read and approve the manuscript.

Corresponding author

Correspondence to Jiong Shi.

Ethics declarations

Declarations: Ethics approval and consent to participate: Institutional Review Board of Beijing Tiantan Hospital approved the protocol (approval number: KY 2019-004-007). We obtained written informed consent from each participant.

Competing interests: None.

Additional information

Trail registration number

NCT04320368.

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Li, S., Dong, H., Wang, Y. et al. China Alzheimer’s Disease and Neurodegenerative Disorder Research (CANDOR) -A Prospective Cohort Study for Alzheimer’s Disease and Vascular Cognitive Impairment. J Prev Alzheimers Dis 11, 214–221 (2024). https://doi.org/10.14283/jpad.2023.97

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  • DOI: https://doi.org/10.14283/jpad.2023.97

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