Abstract
The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.
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Motzkus, D., Albrecht, U. & Maronde, E. The human PER1 gene is inducible by interleukin-6. J Mol Neurosci 18, 105–109 (2002). https://doi.org/10.1385/JMN:18:1-2:105
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DOI: https://doi.org/10.1385/JMN:18:1-2:105