Natural Products Isolation

1. Front Matter

   Pages i-xii

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2. Natural Product Isolation

   • Satyajit D. Sarker, Zahid Latif, Alexander I. Gray

   Pages 1-25

3. Initial and Bulk Extraction

   • Véronique Seidel

   Pages 27-46

4. Supercritical Fluid Extraction

   • Lutfun Nahar, Satyajit D. Sarker

   Pages 47-76

5. An Introduction to Planar Chromatography

   • Simon Gibbons

   Pages 77-116

6. Isolation of Natural Products by Low-Pressure Column Chromatography

   • Raymond G. Reid, Satyajit D. Sarker

   Pages 117-157

7. Isolation by Ion-Exchange Methods

   • David G. Durham

   Pages 159-183

8. Separation by High-Speed Countercurrent Chromatography

   • James B. McAlpine, Patrick Morris

   Pages 185-211

9. Isolation by Preparative High-Performance Liquid Chromatography

   • Zahid Latif

   Pages 213-232

10. Hyphenated Techniques

    • Satyajit D. Sarker, Lutfun Nahar

    Pages 233-267

11. Purification by Solvent Extraction Using Partition Coefficient

    • Hideaki Otsuka

    Pages 269-273

12. Crystallization in Final Stages of Purification

    • Alastair J. Florence, Norman Shankland, Andrea Johnston

    Pages 275-295

13. Dereplication and Partial Identification of Compounds

    • Laurence Dinan

    Pages 297-321

14. Extraction of Plant Secondary Metabolites

    • William P. Jones, A. Douglas Kinghorn

    Pages 323-351

15. Isolation of Marine Natural Products

    • Wael E. Houssen, Marcel Jaspars

    Pages 353-390

16. Isolation of Microbial Natural Products

    • Russell A. Barrow

    Pages 391-414

17. Purification of Water-Soluble Natural Products

    • Yuzuru Shimizu, Bo Li

    Pages 415-438

18. Scale-Up of Natural Product Isolation

    • Steven M. Martin, David A. Kau, Stephen K. Wrigley

    Pages 439-461

19. Follow-Up of Natural Product Isolation

    • Richard J. P. Cannell

    Pages 463-506

20. Back Matter

    Pages 507-515

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The term “natural products” spans an extremely large and diverse range of chemical compounds derived and isolated from biological sources. Our interest in natural products can be traced back thousands of years for their usefulness to humankind, and this continues to the present day. Compounds and extracts derived from the biosphere have found uses in medicine, agriculture, cosmetics, and food in ancient and modern societies around the world. Therefore, the ability to access natural products, understand their usefulness, and derive applications has been a major driving force in the field of natural product research. The first edition of Natural Products Isolation provided readers for the first time with some practical guidance in the process of extraction and isolation of natural products and was the result of Richard Cannell’s unique vision and tireless efforts. Unfortunately, Richard Cannell died in 1999 soon after completing the first edition. We are indebted to him and hope this new edition pays adequate tribute to his excellent work. The first edition laid down the “ground rules” and established the techniques available at the time. Since its publication in 1998, there have been significant developments in some areas in natural product isolation. To capture these developments, publication of a second edition is long overdue, and we believe it brings the work up to date while still covering many basic techniques known to save time and effort, and capable of results equivalent to those from more recent and expensive techniques.

• chromatography
• crystal
• extraction
• natural product

". . . offers extensive help in the selection of a suitable methodology. . .an excellent aid. . .closes a painfully evident gap in the selection of monographs on natural products chemistry. . .warmly recommended to anyone interested in the isolation of natural products."-Angewandte Chemie

". . .a very good general reference that concentrates a considerable amount of useful practical information. . .well worth considering as a reference for graduate students or other researchers who might need to familiarize themselves with the intricacies of the subject."-Journal of Natural Products

"...contains a wealth of practical information, hints, and useful points...an asset in any laboratory where natural products isolation is performed." -Journal of Medicinal Chemistry

"...a very good general reference that concentrates a considerable amount of useful practical information." -Pathology

"...excellent and comprehensive...wholeheartedly recommend[ed]...as a comprehensive handbook for solving problems in daily research." -Drug Discovery Today

• Pharmaceutical Biotechnology Research Group school of Biomedical Sciences, University of Ulster at Coleraine, Coleraine, Northern Ireland, UK

  Satyajit D. Sarker

• Molecular Nature Limited Plas Gogerddan, Aberystwyth, Wales, UK

  Zahid Latif

• Phytochemistry Research Lab Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, Scotland, UK

  Alexander I. Gray

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