Abstract
Diseases with movement disorders may be difficult to diagnose, both at the onset when motor symptoms are mild and not sufficiently specific (e.g., difficulty in manipulating objects), or at the end stage when distinctive motor signs are diluted into a severe and polymorphous clinical picture (e.g., gait disorder with postural instability and cognitive decline in aged patients). Erroneous diagnoses are frequent (1,2), even in the most common idiopathic Parkinson’s disease (PD) (3). Some of these errors may be avoided if the cognitive dysfunctions that often accompany these diseases are included in the diagnostic criteria.
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References
Litvan I, Agid Y, Calne D, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop. Neurology 1996;47:1–9.
Litvan I, Agid Y, Goetz C, et al. Accuracy of clinical diagnosis of corticobasal degeneration. Neurology 1997;48:119–125.
Hughes AJ, Daniel SE, Kilford L, Lees AJ. The accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinicopathological study. J Neurol Neurosurg Psychiatry 1992;55:181–184.
Troster AI, Woods SP, Fields JA, et al. Neuropsychological deficits in essential tremor: an expression of cerebellothalamo-cortical pathophysiology? Eur J Neurol 2002;9:143–151.
Mattis S. Dementia Rating Scale. Odessa, FL: Psychological Assessment Resources Inc., 1988.
Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a Frontal Assessment Battery at bedside. Neurology 2000;55:1621–1626.
Nelson HE. A modified Card Sorting Test sensitive to frontal lobe defect. Cortex 1976;12:313–324.
Benton AL. Differential behavioral effects in frontal lobe disease. Neuropsychologia 1968;6:53–60.
Reitan RM. Validity of the Trail Making Test as an indication of organic brain damage. Percept Mot Skills 1958;8:271–276.
Golden CJ. Stroop Color and Word Test. Chicago: Stoelting Company, 1978.
Luria AR. Higher Cortical Functions in Man. New York, NY: Basic Books, 1966.
Lhermitte F, Pillon B, Serdaru M. Human autonomy and the frontal lobes, I: imitation and utilization behaviors: a neuropsychological study of 75 patients. Ann Neurol 1986;19:326–334.
Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test: Research Edition. New York: Psychological Corporation, 1987.
Grober E, Buschke H. Genuine memory deficits in dementia. Dev Neuropsychol 1987;3:13–36.
Goodglass H, Kaplan E. The Assessment of Aphasia and Related Disorders. Philadelphia: Lea & Febiger, 1976.
Heilman KM, Gonzalez Rothi LJ. Apraxia. In: Heilman KM, Valenstein E, eds. Clinical Neuropsychology, 2nd ed. Oxford: Oxford University Press, 1985:131–150.
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308–2314.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association, 1994.
Quinn N, Critchley P, Marsden CD. Young onset Parkinson’s disease. Mov Disord 1987; 2: 73–91.
Cooper JA, Sagar HJ, Jordan N, Harvey NS, Sullivan EV. Cognitive impairment in early untreated Parkinson’s disease and its relationship to motor disability. Brain 1991;114:2095–2122.
Robbins TW, James M, Lange KW, Owen AM, Quinn NA, Marsden CD. Cognitive performance in Multiple System Atrophy. Brain 1992;115:271–291.
Pillon B, Gouider-Khouja N, Deweer B, et al. Neuropsychological pattern of striatonigral degeneration: comparison with Parkinson’s disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 1995; 58:174–179.
Zetusky WJ, Jankovic J, Pirozzolo FJ. The heterogeneity of Parkinson’s disease: clinical and prognostic implications. Neurology 1985;35:522–526.
Maher ER, Lees AJ. The clinical features and natural history of the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology 1986;36:1005–1008.
Pillon B, Dubois B, Ploska A, Agid Y. Severity and specificity of cognitive impairment in Alzheimer’s, Huntington’s, and Parkinson’s diseases and progressive supranuclear palsy. Neurology 1991;41: 634–643.
Wenning GK, Litvan I, Jankovic J, et al. Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination. J Neurol Neurosurg Psychiatry 1998;64:184–189.
Byrne EJ, Lennox G, Lowe J, Godwin-Austen RB. Diffuse Lewy body disease: clinical features in 15 cases. J Neurol Neurosurg Psychiatry 1989;52:709–717.
Tounsi H, Deweer B, Ergis AM, et al. Sensitivity to semantic cuing: An index of episodic memory dysfunction in early Alzheimer’s disease. Alzheimer disease and associated disorders 1999;13:38–46.
Pillon B, Deweer B, Michon A, Malpand C, Agid Y, Dubois B. Are explicit memory disorders of progressive supranuclear palsy related to damage to striatofrontal circuits? Comparison with Alzheimer’s, Parkinson’s, and Huntington’s diseases. Neurology 1994;44:1254–1270.
Taylor AE, Saint-Cyr JA, Lang AE. Memory and learning in early Parkinson’s disease: evidence for a “frontal lobe syndrome.” Brain Cogn 1990;13:211–232.
Buytenhuijs EJ, Berger JC, van Spaendonck KP, Horstink MW, Borm GF, Cools AR. Memory and learning strategies in patients with Parkinson’s disease. Neuropsychologia 1994;32:335–342.
Pillon B, Blin J, Vidailhet M, et al. The neuropsychological pattern of corticobasal degeneration. Comparison with progressive supranuclear palsy and Alzheimer’s disease. Neurology 1995; 45:1477–1483.
Massman PJ, Kreiter KT, Jankovic J, Doody RS. Neuropsychological functioning in cortical-basal ganglionic degeneration: differenciation from Alzheimer’s disease. Neurology 1996;46:720–726.
Connor DJ, Salmon DP, Sandy TJ, Galasko D, Hansen LA, Thal L. Cognitive profiles of autopsy-confirmed Lewy body variant vs pure Alzheimer’s disease. Arch Neurol 1998; 55:994–1000.
Brown RG, Marsden CD. “Subcortical dementia”: the neuropsychological evidence. Neurosci 1988; 25:363–387.
Leiguarda R, Merello M, Nouzeilles MI, Balej J, Rivero A, Nagues M. Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. Mov Disord 2003;18:49–59.
Maher ER, Smith EM, Lees AJ. Cognitive deficits in the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). J Neurol Neurosurg Psychiatry 1985;48:1234–1239.
Ross GW, Mahler ME, Cummings JL. The dementia syndromes of Parkinson’s disease: cortical and subcortical features. In: Huber SJ, Cummings JL, eds. Parkinson’s Disease: Neurobehavioral Aspects. Oxford: Oxford University Press,1992:132–148.
Taylor AE, Saint-Cyr JA, Lang AE. Frontal lobe dysfunction in Parkinson’s disease. Brain 1986; 109:845–883.
Owen AM, Robbins TW. Comparative neuropsychology of Parkinsonian syndromes. In: Wolters EC, Scheltens P, eds. Mental Dysfunction in Parkinson’s Disease. Proceedings of the European Congress on Mental Dysfunction in Parkinson’s Disease held in Amsterdam on 20–23 October 1993. Amsterdam: Vrije Universiteit, 1993: 221–241.
Cummings JL. Psychosis in basal ganglia disorders. In: E Wolters E, Scheltens P, eds. Mental Dysfunction in Parkinson’s Disease. Proceedings of the European Congress on Mental Dysfunction in Parkinson’s Disease held in Amsterdam on 20–23 October 1993. Amsterdam: Vrije Universiteit, 1993: 257–268.
Litvan I, Paulsen JS, Mega MS, Cummings JL. Neuropsychiatric assessment of patients with hyperkinetic and hypokinetic movement disorders. Arch Neurol 1998;55:1313–1319
Litvan I, Mega MS, Cummings JL, Fairbanks L. Neuropsychiatric aspects of progressive supranuclear palsy. Neurology 1996;47:1184–1189.
Aarsland D, Ballard G, Larsen JP, McKeith I. A comparative study of psychiatric symptoms in dementia with diffuse Lewy body disease and Parkinson’s disease with and without dementia. Int J Geriatr Psychiatry 2001; 16:528–536.
Cummings JL, Litvan I. Neuropsychiatric aspects of corticobasal degeneration. In: Litvan I, Goetz CG, Lang AE, eds. Corticobasal Degeneration. Advances in Neurology, vol. 82. Philadelphia: Lippincott, Williams & Wilkins, 2000:147–152.
Pillon B, Boller F, Levy R, Dubois B. Cognitive deficits and dementia in Parkinson’s disease. In: Boller F, Grafman J (eds.). Handbook of Neuropsychology, vol 6. Aging and Dementia. Amsterdam: Elsevier, 2001:311–371.
Slaughter JR, Slaughter KA, Nichols D, Holmes SE, Martens MP. Prevalence, clinical manifestations, etiology, and treatment of depression in Parkinson’s disease. J Neuropsychiatry Clin Neurosci 2001;13: 187–196.
Pluck GC, Brown RG. Apathy in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2002;73: 636–642.
Czernecki V, Pillon B, Houeto JL, Pachon JB, Levy R, Dubois B. Motivation, reward, and Parkinson’s disease: influence of dopatherapy. Neuropsychologia 2002;40:2257–2267.
Katzen HL, Levin BE, Llabre ML. Age of disease onset influences cognition in Parkinson’s disease. J Int Neuropsychol Soc 1998;4:285–290.
Meco G, Gasparini M, Doricchi F. Attentional functions in multiple system atrophy and Parkinson’s disease. J Neurol Neurosurg Psychiatry 1996;60:393–398.
Soliveri P, Monza D, Paridi D, et al. Neuropsychological follow-up in patients with Parkinson’s disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 2000;69:313–318.
Brown RG, Pillon B, Uttner I, and Members of the Neuropsychology Working Group and NNIPPS Consortium, France, Germany, UK. Cognitive function in patients with progressive supranuclear palsy and multiple system atrophy. The Movement Disorder Society, 7th International Congress of Parkinson’s disease and Movement Disorders, November 2002. Book of Abstracts, 2002, P706.
Ghika J. Mood and behavior in disorders of the basal ganglia. In: Bogousslavsky J, Cummings JL, eds. Behavior and Mood Disorders in Focal Brain Lesions. Cambridge: Cambridge University Press, 2000:122–200.
Dubois B, Pillon B, Legault F, Ajid Y, Lhermitte F. Slowing of cognitive processing in progressive supranuclear palsy. A comparison with Parkinson’s disease. Arch Neurol 1988;45:1194–1199.
Johnson R. Event-related brain potentials. In: Litvan I, Agid Y, eds. Progressive Supranuclear Palsy. Oxford: Oxford University Press, 1992:122–154.
Grafman J, Litvan I, Stark M. Neuropsychological features of progressive supranuclear palsy. Brain Cogn 1995;28:311–320.
Esmonde T, Giles E, Xuereb J, Hodges J. Progressive supranuclear palsy presenting with dynamic aphasia. J Neurol Neurosurg Psychiatry 1996;60:403–410.
Pharr V, Uttl B, Stark M, Litvan I, Fantie B, Grafman J. Comparison of apraxia in corticobasal degeneration and progressive supranuclear palsy. Neurology 2001;56:957–963.
Dubois B, Défontaines B, Deweer B, Malapani C, Pillon B. Cognitive and behavioral changes in patients with focal lesions of the basal ganglia. In: Weiner WJ, Lang AE, eds. Behavioral Neurology of Movement Disorders. Advances in Neurology, vol. 65. New York: Raven, 1995: 29–41.
Slachevsky A, Pillon B, Beato R, et al. The “Signe de l’Applaudissement” in PSP. American Academy of Neurology 54th Annual Meeting, Denver, April 13–20, 2002. Neurology 2002;58(Suppl 3): P06.139.
Kertez A, Martinez-Lage P, Davidson W, Munoz DJ. The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology 2000;55:1368–1375.
Bergeron C, Davis A, Lang AE. Corticobasal ganglionic degeneration and progressive supranuclear palsy presenting with cognitive decline. Brain Pathology 1998;8:355–365.
Lang AE, Maragonore D, Marsden CD, et al. Movement Disorder Society Symposium on cortico-basal ganglionic degeneration (CBGD) and its relationship to other asymmetrical cortical degeneration syndromes. Mov Disord 1996; 11:346–357.
Leiguarda R, Lees AJ, Merello M, Starkstein S, Marsden CD. The nature of apraxia in corticobasal degeneration. J Neurol Neurosurg Psychiatry 1994;57:455–459.
Spatt J, Bak T, Bozeat S, Patterson K, Hodges JR. Apraxia, mechanical problem solving and semantic knowledge: contributions to object usage in corticobasal degeneration. J Neurol 2002;249:601–608.
Frattali CM, Grafman J, Patronas N, Makhlouf MS, Litvan I. Language disturbances in corticobasal degeneration. Neurology 2000;54:990–992.
Grimes DA, Lang AE, Bergeron C. Dementia is the most common presentation of corticobasal ganglionic degeneration. Neurology 1999;53:1969–1974.
Barber R, Panikkar A, McKeith IG. Dementia with Lewy bodies: diagnosis and management. Int J Geriatr Psychiatry 2001;16(Suppl 1):12–18.
Gnanalingham K, Byrne E, Thornton A, Samabrook MA, Bannister P. Motor and cognitive function in Lewy body dementia: comparison with Alzheimer’s and Parkinson’s disease. J Neurol Neurosurg Psychiatry 1997; 62:243–252.
Ballard CG, Aarsland D, McKeith I, et al. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology 2002;59:1714–1720.
Aarsland D, Litvan I, Salmon D, Galasko D, Wentzel-larsen T, Larsen JP. Performance on the dementia rating scale in Parkinson’s disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2003;74:1215–1220.
Apaydin H, Ahlskog JE, Parisi JE, Boeve BF, Dickson DW. Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response. Arch Neurol 2002;59:102–112.
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Dubois, B., Pillon, B. (2005). Added Value of the Neuropsychological Evaluation for Diagnosis and Research of Atypical Parkinsonian Disorders. In: Litvan, I. (eds) Atypical Parkinsonian Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-834-X:185
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DOI: https://doi.org/10.1385/1-59259-834-X:185
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