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Conditional Survival of Patients with Limited-Stage Small Cell Lung Cancer After Surgery: A National Real-World Cohort Study

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The prognosis of limited-stage small cell lung cancer (LS-SCLC) after surgery usually is estimated at diagnosis, but how the prognosis actually evolves over time for patients who survived for a predefined time is unknown.

Methods

Data on patients with a diagnosis of LS-SCLC after surgery between 2004 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. The 5-year conditional cancer-specific survival (CCSS) and conditional overall survival (COS) were calculated.

Results

This study analyzed 997 patients (555 women, 55.7%) with a median age, of 67 years (interquartile range [IQR], 60–73 years). The 5-year CCSS and COS increased from 44.7% and 38.3%, respectively, at diagnosis to 83.7% and 67.9% at 5 years after diagnosis. Although there were large differences with different stages (stages I, II, and III) at diagnosis (respectively 59.5%, 28.4%; 28.1% for CCSS and 50.6%, 24.8%, and 23.6% for COS), the gap decreased with time, and the rates were similar after 5 years (respectively 85.0%, 80.3%, and 79.4% for CCSS; 65.6%, 56.9%, and 61.3% for COS). The 5-year conditional survival for the patients who received lobectomy was better than for those who received sublobectomy or pneumonectomy. Multivariable analyses showed that only age and resection type were independent predictors for CCSS and COS, respectively, throughout the period.

Conclusion

Conditional survival estimates for LS-SCLC generally increased over time, with the most significant improvement in patients with advanced stage of disease. Resection type and old age represented extremely important determinants of prognosis after a lengthy event-free follow-up period.

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Data availability

All the data are available in a public, open-access repository.

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Acknowledgements

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Authors and Affiliations

  1. Department of Thoracic Oncology Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China

    Jun-Peng Lin PhD, Xiao-Feng Chen MD, Peiyuan Wang PhD, Hao He MD, Wei-Jie Chen MD, Feng-Nian Zhuang MD, Hang Zhou MD, Yu-Jie Chen MD, Wen-Wei Wei MD, Shuo-Yan Liu MD & Feng Wang MD

  2. Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, China

    Jun-Peng Lin PhD, Xiao-Feng Chen MD, Peiyuan Wang PhD, Hao He MD, Wei-Jie Chen MD, Feng-Nian Zhuang MD, Hang Zhou MD, Yu-Jie Chen MD, Wen-Wei Wei MD, Shuo-Yan Liu MD & Feng Wang MD

  3. Fujian Provincial Key Laboratory of Tumor Biotherapy, Fuzhou, China

    Jun-Peng Lin PhD, Xiao-Feng Chen MD, Peiyuan Wang PhD, Hao He MD, Wei-Jie Chen MD, Feng-Nian Zhuang MD, Hang Zhou MD, Yu-Jie Chen MD, Wen-Wei Wei MD, Shuo-Yan Liu MD & Feng Wang MD

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  1. Jun-Peng Lin PhD
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Contributions

Jun-Peng Lin, Shuo-Yan Liu, Feng Wang, and Xiao-Feng Chen contributed to the conception and design. Jun-Peng Lin, Pei-Yuan Wang, Hang Zhou, and Feng-Nian Zhuang collected and analyzed the data. Jun-Peng Lin, Yu-Jie Chen, Wen-Wei Wei, and Hao He drew the figures and tables. Jun-Peng Lin wrote the draft. Jun-Peng Lin, Wei-Jie Chen, Feng Wang, and Shuo-Yan Liu contributed to manuscript writing and revision. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Shuo-Yan Liu MD or Feng Wang MD.

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Ethical approval was not required for the use of anonymized publicly available data.

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Lin, JP., Chen, XF., Wang, P. et al. Conditional Survival of Patients with Limited-Stage Small Cell Lung Cancer After Surgery: A National Real-World Cohort Study. Ann Surg Oncol (2024). https://doi.org/10.1245/s10434-024-14983-w

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