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Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

  • Gynecologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality that aims to target the main site of tumor dissemination in ovarian cancer, the peritoneum, by combining the benefits of intraperitoneal chemotherapy with the synergistic effects of hyperthermia all during a single administration at the time of cytoreductive surgery. High-quality evidence currently only supports the use of HIPEC with cisplatin at the time of interval cytoreduction after neoadjuvant chemotherapy for stage III epithelial ovarian cancer. Many questions remain, including HIPEC’s role at other timepoints in ovarian cancer treatment, who are optimal candidates, and specifics of HIPEC protocols. This article reviews the history of normothermic and hyperthermic intraperitoneal chemotherapy in ovarian cancer and evidence regarding HIPEC implementation and patient outcomes. Additionally, this review explores details of HIPEC technique and perioperative care, cost considerations, complication and quality of life data, disparities in HIPEC use, and unresolved issues.

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Authors and Affiliations

  1. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

    Julia H. Gelissen MD, Blair McNamara MD, Levent Mutlu MD, Justin A. Harold MD, Mitchell Clark MD, Gary Altwerger MD, Peter R. Dottino MD, Gloria S. Huang MD, Alessandro D. Santin MD, Masoud Azodi MD, Elena Ratner MD, MBA, Peter E. Schwartz MD & Vaagn Andikyan MD

  2. Gynecologic Oncology and Reproductive Medicine Department, MD Anderson Cancer Center, Houston, TX, USA

    Naomi N. Adjei MD, MPH, MSEd

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Gelissen, J.H., Adjei, N.N., McNamara, B. et al. Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. Ann Surg Oncol 30, 5597–5609 (2023). https://doi.org/10.1245/s10434-023-13757-0

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  • DOI: https://doi.org/10.1245/s10434-023-13757-0

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