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Outcomes of a Phase II Study of Intraperitoneal Paclitaxel Plus Systemic Capecitabine and Oxaliplatin (XELOX) for Gastric Cancer with Peritoneal Metastases

  • Peritoneal Surface Malignancy
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  1. Chia DKA, Sundar R, Kim G, et al. Outcomes of a phase II study of intraperitoneal paclitaxel plus systemic capecitabine and oxaliplatin (XELOX) for gastric cancer with peritoneal metastases. Ann Surg Oncol. 2022. https://doi.org/10.1245/s10434-022-11998-z (PMID: 36070113).

    Article  Google Scholar 

  2. Bonnot PE, Lintis A, Mercier F, et al. Prognosis of poorly cohesive gastric cancer after complete cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (CYTO-CHIP study). Br J Surg. 2021;108:1225–35. https://doi.org/10.1093/bjs/znab200 (PMID: 34498666).

    Article  CAS  Google Scholar 

  3. Rau, B., Lang, H., Königsrainer A, et al.: The effect of hyperthermic intraperitoneal chemotherapy (HIPEC) upon cytoreductive surgery (CRS) in gastric cancer (GC) with synchronous peritoneal metastasis (PM): a randomized multicentre phase III trial (GASTRIPEC-I-trial). Abstract 13760, Proffered paper session–gastrointestinal tumours, non-colorectal, ESMO Congress (2021)

  4. Yoshida K, Yasufuku I, Terashima M, et al. CONVO-GC-1 Study Group, Federation of Asian Clinical Oncology (FACO). International retrospective cohort study of conversion therapy for stage IV gastric cancer 1 (CONVO-GC-1). Ann Gastroenterol Surg. 2021;6:227–40. https://doi.org/10.1002/ags3.12515 (PMID: 35261948 PMCID: PMC8889854).

    Article  Google Scholar 

  5. Bonnot PE, Piessen G, Kepenekian V, et al. Cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastases (CYTO-CHIP study): a propensity score analysis. J Clin Oncol. 2019;37:2028–40. https://doi.org/10.1200/JCO.18.01688 (PMID: 31084544).

    Article  CAS  Google Scholar 

  6. Ishigami H, Fujiwara Y, Fukushima R, et al. Phase III trial comparing intraperitoneal and intravenous paclitaxel plus S-1 versus cisplatin plus S-1 in patients with gastric cancer with peritoneal metastasis: PHOENIX-GC trial. J Clin Oncol. 2018;36:1922–9. https://doi.org/10.1200/JCO.2018.77.8613 (PMID: 29746229).

    Article  CAS  Google Scholar 

  7. Eveno C, Jouvin I, Pocard M. PIPAC EstoK 01: pressurized intraperitoneal aerosol chemotherapy with cisplatin and doxorubicin (PIPAC C/D) in gastric peritoneal metastasis: a randomized and multicenter phase II study. Pleura Peritoneum. 2018;3:20180116. https://doi.org/10.1515/pp-2018-0116 (PMID: 30911659 PMCID: PMC6405009).

    Article  Google Scholar 

  8. Badgwell B, Ikoma N, Murphy MB, et al. A phase II trial of cytoreduction, gastrectomy, and hyperthermic intraperitoneal perfusion with chemotherapy for patients with gastric cancer and carcinomatosis or positive cytology. Ann Surg Oncol. 2021;28:258–64. https://doi.org/10.1245/s10434-020-08739-5 (PMID: 32556731).

    Article  Google Scholar 

  9. Basile D, Simionato F, Cappetta A, et al. State-of-the-art of monoclonal antibodies for the treatment of gastric cancer. Biologics. 2021;15:451–62. https://doi.org/10.2147/BTT.S290323 (PMID: 34764633 PMCID: PMC8572727).

    Article  Google Scholar 

  10. Gwee YX, Chia DKA, So J, et al. Integration of genomic biology into therapeutic strategies of gastric cancer peritoneal metastasis. J Clin Oncol. 2022;40:2830. https://doi.org/10.1200/JCO.21.02745 (PMID: 35649219 PMCID: PMC9390822).

    Article  CAS  Google Scholar 

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Correspondence to Jimmy B. Y. So MPH, FRCS.

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Disclosure

This study was supported by the National Medical Research Council (NMRC) Translational and Clinical Flagship Programme (NMRC/TCR/009-NUHS/2013), NMRC Centre Grants (NMRC/CG/012/2013, NMRC/CG/M005/2017_NCIS) and NMRC Open Fund Large Collaborative Grant (OFLCG18May-9923). Dr Raghav Sundar is also supported by a NMRC Fellowships (NMRC/Fellowship/0059/2018 and NMRC/MOH/000627). Trial registry: NCT01739894.

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Chia, D.K.A., Sundar, R., Kim, G. et al. Outcomes of a Phase II Study of Intraperitoneal Paclitaxel Plus Systemic Capecitabine and Oxaliplatin (XELOX) for Gastric Cancer with Peritoneal Metastases. Ann Surg Oncol 30, 1889–1890 (2023). https://doi.org/10.1245/s10434-022-12877-3

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  • DOI: https://doi.org/10.1245/s10434-022-12877-3

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