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The Feasibility of Early Oral Feeding After Neoadjuvant Chemotherapy Combined With “Non-Tube No Fasting”-Enhanced Recovery

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

This study aimed to investigate the feasibility of early oral feeding (EOF) after neoadjuvant chemotherapy (nCT) combined with “non-tube no fasting”-enhanced recovery after minimally invasive esophagectomy (MIE).

Methods

This retrospective study investigated patients who underwent nCT combined with non-tube no fasting-enhanced recovery after MIE in the Department of Thoracic Surgery, Ward I, of the authors’ hospital from January 2014 to August 2017. These patients were divided into an early oral feeding (EOF) group (n = 112) and a late oral feeding (LOF) group (n = 69). The postoperative complications were compared between the two groups.

Results

The study enrolled 181 patients (112 patients in the EOF group and 69 patients in the LOF group). No significant differences were found between the two groups in the incidence rates of complications such as anastomotic leakage (P = 0.961), pneumonia (P = 0.450), respiratory failure (P = 0.944), heart failure (P = 1.000), acute respiratory distress syndrome (ARDS) (P = 0.856), and unplanned reoperation (P = 0.440), whereas the time to the first postoperative flatus/bowel movement (P < 0.001) and the postoperative length of stay (P < 0.001) were significantly better in the EOF group than in the LOF group..

Conclusions

In this study, EOF after nCT combined with non-tube no fasting-enhanced recovery after MIE did not significantly increase complications, but significantly shortened the time to the first postoperative flatus/bowel movement and the postoperative length of stay.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China, NSFC (Grant no. 82002521); the Natural Science Foundation of Henan Province, China (Grant No. 202300410389); the Henan Anti-Cancer Association Youth Talent Project, China (Grant No. 2019HYTP018, 2019); the Wu Jieping Medical Foundation (CN), China (Grant no. 320.6750.2020-15-1); the Henan Province health science and technology innovation outstanding young talents training project, China (YXKC2021029); and the Henan Province Medical Science and Technology Key Projects Co-Constructed by the Ministry of Health, China (Thoracic Surgery-3202730).2

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Author notes

  1. Wentao Hao, Kun Gao and Keting Li have contributed equally to this work.

Authors and Affiliations

  1. Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China

    Wentao Hao MD, Kun Gao MD, Keting Li MD, Yin Li MD, PhD, Zongfei Wang MD, Haibo Sun MD, PhD, Wenqun Xing MD & Yan Zheng MD, PhD

  2. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Yin Li MD, PhD

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Hao, W., Gao, K., Li, K. et al. The Feasibility of Early Oral Feeding After Neoadjuvant Chemotherapy Combined With “Non-Tube No Fasting”-Enhanced Recovery. Ann Surg Oncol 30, 1564–1571 (2023). https://doi.org/10.1245/s10434-022-12620-y

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