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Percutaneous Radiofrequency Ablation of Pulmonary Metastases from Colorectal Carcinoma: Prognostic Determinants for Survival

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Abstract

Background

Preliminary results have shown that percutaneous radiofrequency ablation (RFA) may play a useful role in patients with inoperable lung tumors. This series evaluated the prognostic features for survival in nonsurgical candidates who underwent percutaneous RFA of pulmonary metastases from colorectal carcinoma.

Methods

Fifty-five patients not suitable for surgery underwent percutaneous RFA for colorectal pulmonary metastases. All clinical and treatment-related data were collected prospectively. The primary end point of the study was overall survival, defined from the time of RFA intervention. Univariate and multivariate analyses were performed to identify statistically significant prognostic parameters for overall survival.

Results

The overall median survival was 33 months (range, 4–40 months), with actuarial 1-, 2-, and 3-year survival of 85%, 64%, and 46%, respectively. Univariate analysis demonstrated that largest size of lung metastasis (P < .001), location of lung metastases (P = .032), and repeat percutaneous RFA for pulmonary recurrence (P = .024) were statistically significant for overall survival. Multivariate analysis demonstrated that largest size of lung metastasis >3 cm was independently associated with a reduced overall survival (P = .003).

Conclusions

Percutaneous lung RFA may play a useful role in nonsurgical candidates with colorectal pulmonary metastases. However, the survival benefit of this interventional procedure for patients with a pulmonary metastasis >3 cm was limited.

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Acknowledgments

The authors thank Jing Zhao for her diligent and meticulous work in maintaining the RFA database and David Change for his expertise in statistical analysis.

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Authors and Affiliations

  1. Department of Surgery, University of New South Wales, St. George Hospital, Sydney, New South Wales, 2217, Australia

    Tristan D. Yan BSc (Med), MBBS, Julie King MPH, Adrian Sjarif MBBS, Karin Steinke MD & David L. Morris MD, PhD

  2. Department of Radiology, University of New South Wales, St. George Hospital, Sydney, New South Wales, 2217, Australia

    Derek Glenn FRACR & Karin Steinke MD

Authors
  1. Tristan D. Yan BSc (Med), MBBS
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  2. Julie King MPH
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  3. Adrian Sjarif MBBS
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  4. Derek Glenn FRACR
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  5. Karin Steinke MD
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  6. David L. Morris MD, PhD
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Corresponding author

Correspondence to Tristan D. Yan BSc (Med), MBBS.

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Yan, T.D., King, J., Sjarif, A. et al. Percutaneous Radiofrequency Ablation of Pulmonary Metastases from Colorectal Carcinoma: Prognostic Determinants for Survival. Ann Surg Oncol 13, 1529–1537 (2006). https://doi.org/10.1245/s10434-006-9101-1

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  • DOI: https://doi.org/10.1245/s10434-006-9101-1

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