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Chitosan/Polylactic Acid Nanofibers Containing Astragaloside IV as a New Biodegradable Wound Dressing for Wound Healing

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Abstract

The ideal wound dressing should adequately protect the wound from bacterial infection and provide a suitable healing environment for the wound. Thus, we prepared a biodegradable functional nanofiber dressing with good antibacterial and biocompatibility by electrospinning technology. The average diameter of the dressing was 354 ± 185 nm, and the porosity was 93.27%. Scanning electron microscopy (SEM) showed that the dressing was smooth without beading. It was also characterized by Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The wettability and water vapor permeability of the dressing were tested; the results showed that the dressing had good wettability and permeability. The ability of drug release indicates that continuous release over a period of time is beneficial to wound healing. Finally, the antibacterial effect and in vivo pharmacodynamic evaluation of AS/CS/PLA nanofiber dressing were studied; the result showed that it had significant antibacterial activity and the ability to promote wound healing.

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Funding

This experiment was supported by project of Guizhou Traditional Chinese Medicine Administration (QZYY-2020–039), Guizhou Provincial Health Commission Science and Technology Fund Project (zwkj2022-234), and Young Scientific and Technological Talents Growth Project of Guizhou Provincial Department of Education (Qian Jiao He KY Zi(2018)205).

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Authors and Affiliations

  1. Guizhou University of Traditional Chinese Medicine, Guiyang, 550000, Guizhou, China

    Zemei Liu, Yuanju Lv, Guangyan Zheng, Wenli Wu & Xin Che

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  1. Zemei Liu
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  2. Yuanju Lv
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  3. Guangyan Zheng
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  4. Wenli Wu
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  5. Xin Che
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Contributions

All authors contributed to the data analysis, drafting, and analysis; made rigorous revisions to the paper; gave final approval for publication; and agreed to take responsibility for all aspects of the work. ZL conceived and designed the experiment and wrote the paper. ZL and YL conducted the experiment. GZ and WW conducted the analysis of Fourier infrared spectroscopy and X-ray diffraction, and XC reviewed the manuscript.

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Correspondence to Xin Che.

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Liu, Z., Lv, Y., Zheng, G. et al. Chitosan/Polylactic Acid Nanofibers Containing Astragaloside IV as a New Biodegradable Wound Dressing for Wound Healing. AAPS PharmSciTech 24, 202 (2023). https://doi.org/10.1208/s12249-023-02650-4

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