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Biologically Active Coordination Compounds of Germanium. Synthesis and Physicochemical Properties

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Abstract

A promising area of modern coordination and supramolecular chemistry is the synthesis of biologically active compounds of germanium and creation of effective drugs, biomaterials, and enzyme modulators based thereon. The present review deals with biologically active compounds of germanium(IV) and contributes to the solution of problems of synthesis, physicochemical analysis, and prediction of biological activity of germanium complexes with a wide spectrum of action. Some features of coordination and chemical properties of organic acids and amino acids in the complexation with germanium dioxide and chloride have been demonstrated. The literature data on the complexation conditions, crystal and supramolecular structures of germanium(IV) complexes, geometry of germanium coordination polyhedra, types of hydrogen bonds, topology of coordination shells, and pharmacological and biological properties of a number of compounds are considered.

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REFERENCES

  1. Emsley, J., The Elements, Oxford: Clarendon, 1989.

  2. Asai, K., JPN Patent no. 46-2964, 1971.

  3. Asai, K., JPN Patent no. 60-41472, 1985.

  4. Asai, K., JPN Patent no. 59-25677, 1984.

  5. Aso, H., Suzuki, F., Ebina, T., and Ishida, N., J. Biol. Response Modif., 1989, vol. 8, p. 180.

    CAS  Google Scholar 

  6. Unakar, N.J., Tsui, J., and Johnson, M., Curr. Eye Res., 1997, vol. 16, p. 832. https://doi.org/10.1016/s0014-4835(05)80035-1

    Article  CAS  PubMed  Google Scholar 

  7. Timchishin, O.L., Kresyun, V.I., and Godovan, V.V., Dosyagnennya Bіol. Med., 2011, no. 2, p. 64. https://doi.org/10.17816/KMJ1905

    Article  Google Scholar 

  8. Ambrosov, I.V., Aleshin, S.V., Alimbarova, L.M., Matelo, S.K., and Shokhin, I.E., Razrab. Regist. Lek. Sredstv, 2015, no. 2, p. 144.

    Google Scholar 

  9. Asbury, R.F., Cnaan, M.D., Harris, L., Zaentz, S., and Haller, D., Am. J. Clin. Oncol., 1994, vol. 17, p. 166. https://doi.org/10.1097/00000421-199404000-00016

    Article  CAS  PubMed  Google Scholar 

  10. Ekologicheskaya geokhimiya elementov (Ecological Chemistry of Elements), Moscow: Nedra, 1994, vol. 3.

  11. Rebrov, V.G. and Gromova, O.A., Vitaminy i mikroelementy (Vitamins and Trace Elements), Moscow, 2003.

  12. Galchenko, V.M., Byval’tseva, S.Yu., Galchesnko, L.I., and Fedotova, M.V., Parodontologiya, 2017, vol. 22, p. 89.

    Google Scholar 

  13. Dolaychuk, O.P., Fedoruk, R.S., Kovalchuk, I.I., and Kropyvka, S.Y., Bіol. Tvarin, 2015, vol. 17, p. 50. https://doi.org/10.15407/animbiol17.02.050

    Article  Google Scholar 

  14. Choi, S., Oh, C., Han, J., and Park, J., Eur. J. Med. Chem., 2010, vol. 45, p. 1654. https://doi.org/10.1016/j.ejmech.2009.12.069

    Article  CAS  PubMed  Google Scholar 

  15. Lukevits, E.Ya., Gar, T.K, Ignatovich, L.M., and Mironov, V.F., Biologicheskaya aktivnost’ soedinenii germaniya (Biological Activity of Germanium Compounds), Riga: Zinatne, 1990.

  16. Mariusz, K., Crit. Rev. Anal. Chem., 2008, vol. 38, p. 84. https://doi.org/10.1080/10408340701804459

    Article  CAS  Google Scholar 

  17. Lukevics, E. and Ignatovich, L., Appl. Organomet. Chem., 1992, vol. 6, p. 113. https://doi.org/10.1002/aoc.590060204

    Article  CAS  Google Scholar 

  18. Aleshin, S.V., Ambrosov, I.V., Matelo, S.K., and Shokhin, I.E., Sorbtsionnye Khromatogr. Protsessy, 2016, vol. 16, p. 93.

    CAS  Google Scholar 

  19. Isaev, A.D., Ambrosov, I.V, Manasherov, T.O., and Matelo, S.K., RU Patent no. 2487878, 2006.

  20. Zhang, Ch.L., Li, T.H., Niu, Sh.H., Wang, R.F., Fu, Zh.L., Guo, F.Q., and Yang, M., Bioinorg. Chem. Appl., 2009, vol. 2009, article ID 908625. https://doi.org/10.1155/2009/908625

  21. Zhang, L.H., Kamanna, V.S., and Ganji, S.H., J. Lipid. Res., 2012, vol. 53, p. 941.

    Article  CAS  Google Scholar 

  22. Song, W.L. and FitzGerald, G.A., J. Lipid. Res., 2013, vol. 54, p. 2586. https://doi.org/10.1194/jlr.R040592

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Nіzhenkovs’ka, І.V., Narokha, V.P., Kuznetsova, O.V., Bryuzgіna, T.S., Seifullіna, І.I., Martsinko, O.E., and Chebanenko, O.A., Farmakol. Lіkar. Toksikol., 2015, no. 1, p. 68.

    Google Scholar 

  24. Asai, K., Miracle Cure, 1980.

  25. Revina, A.A., RU Patent no. 2322327, 2007.

  26. Menchikov, L.G. and Ignatenko, M.A., Pharm. Chem. J., 2012, vol. 46, p. 635. https://doi.org/10.1007/s11094-013-0860-2

    Article  CAS  Google Scholar 

  27. Kadomtseva, A.V., Zhdanovich, I.V., Piskunova, M.S., Lineva, A.N., Novikova, A.N., and Loginov, P.A., Toksikol. Vestn., 2019, no. 2, p. 16.

    Article  Google Scholar 

  28. Shemonaeva, E.F., Kresyun, V.I., Vidavskaya, A.G., and Seifullina, I.I., Sovrem. Tendentsii Razvit. Nauki Tekhnol., 2016, no. 9, p. 59.

    Google Scholar 

  29. Tymchishin, O.L., Kazan. Med. Zh., 2013, vol. 94, p. 628–632. https://doi.org/10.17816/KMJ1905

    Article  Google Scholar 

  30. Le Nhat Thuy Giang, Baryshok, V.P., and Voronkov, M.G., Butlerov. Commun., 2013, vol. 36, p. 57.

    Google Scholar 

  31. Voronkov, M.G., Abzaeva, K.A., and Fedorin, A.Yu., Genezis i evolyutsiya khimii organicheskikh soedinenii germaniya, olova i svintsa (Genesis and Development of the Chemistry of Organic Compounds of Germanium, Tin, and Lead), Novosibirsk: Geo, 2012.

  32. Zaitseva, E.A., Troinich, Ya.N., Lebedinskaya, O.V., Lyashenko, V.A., and Akhmatova, N.K., Med. Immunol., 2015, vol. 17, p. 388.

    Google Scholar 

  33. Lavrent’eva, I.N., Semenov, A.V., Ambrosov, I.V., Matelo, S.K., Agrba, V.Z., and Karal-ogly, D.D., Med. Immunol., 2015, vol. 17, p. 403.

    Google Scholar 

  34. Lyashenko, V.A., Akhmatova, E.A., Zaitseva, E.A., Akhmatova, N.K., Lebedinskaya, O.V., and Krasnoporshina, L.I., Med. Immunol., 2015, vol. 17, p. 405.

    Google Scholar 

  35. Ukolova, N.Yu., Surkichin, S.I., Matelo, S.K., Isaev, A.D., Ambrosov, I.V., Dirsh, A.V., and Kostkina, E.A., Klin. Dermatol. Venerol., 2017, no. 1, p. 49.

    Article  Google Scholar 

  36. Terent’ev, A.O., Platonov, M.M., Levitskii, D.O., and Dembitskii, V.M., Russ. Chem. Rev., 2011, vol. 80, p. 807. https://doi.org/10.1070/RC2011v080n09ABEH004189

    Article  CAS  Google Scholar 

  37. Sluchevskaya, N.P., Yablokov, V.A., Yablokova, N.V., and Aleksandrov, Yu.A., Zh. Obshch. Khim., 1976, vol. 46, p. 2724.

    CAS  Google Scholar 

  38. Seifullina, I.I., Martsinko, E.E., Khristova, N.M., and Chebanenko, E.A., Visn. Odes. Nats. Univ., Khim., 2017, vol. 21, p. 18.

    Google Scholar 

  39. Martsinko, E.E., Seifullina, I.I., Minacheva, L.Kh., Pesaroglo, L.G., and Sergienko, V.S., Russ. J. Inorg. Chem., 2008, vol. 53, p. 1694. https://doi.org/10.1134/S0036023608110053

    Article  Google Scholar 

  40. Seifullina, I.I., Pesaroglo, L.G., Minacheva, L.Kh., Martsinko, E.E., and Sergienko, V.S., Russ. J. Inorg. Chem., 2006, vol. 51, p. 1892. https://doi.org/10.1134/S0036023606120096

    Article  Google Scholar 

  41. Seifullina, I.I., Pesaroglo, A.G., Minacheva, L.Kh., Martsinko, E.E., and Sergienko, V.S., Russ. J. Inorg. Chem., 2007, vol. 52, p. 494. https://doi.org/10.1134/S0036023607040055

    Article  Google Scholar 

  42. Seifullina, I.I. and Martsinko, E.E., Koordinatsionnye soedineniya germaniya(IV) s anionami limonnoi, vinnoi i ksilarovoi kislot [Coordination Compounds of Gemanium(IV) with Citric, Tartaric, and Xylaric Acid Anions]. Odessa: Odessk. Nats. Univ. Imeni I.I. Mechnikova, 2015, p. 99.

  43. King, M.D., Davis, E.A., and Smith, T.M., J. Phys. Chem., 2011, vol. 115, p. 11039. https://doi.org/10.1021/jp204750v

    Article  CAS  Google Scholar 

  44. Varbanets’, O.І., Godovan, V.V., and Martsinko, O.E., Odes. Med. Zh., 2012, no. 4, p. 15. https://doi.org/10.18524/2304-0947.2016.3(59).79565

    Article  Google Scholar 

  45. Merget, M., Günther, K., Bernd, M., Günther, E., and Tacke, R., J. Organomet. Chem., 2014, vol. 628, p. 183. https://doi.org/10.1016/S0022-328X(01)00783-5

    Article  Google Scholar 

  46. Choudhary. M.A., Mazhar, M., Ali, S., Song, X., and Eng, G., Met.-Based Drugs, 2016, vol. 8, article ID 726152. https://doi.org/10.1155/MBD.2002.275

  47. Kaleem, K.M., Mazhar, M., Sarim, D., Khadija, S., and Farnaz, M., Turk. J. Chem., 2006, vol. 30, p. 345.

    Google Scholar 

  48. Kaleem, K.M., Mazhar, M., Saqib, A., and Sarim, D., Turk. J. Chem., 2010, vol. 34, p. 387. https://doi.org/10.3906/kim-0904-10

    Article  CAS  Google Scholar 

  49. Chen, R., Liu, L., and Zhang, Z., Heteroat. Chem., 1997, vol. 6, p. 503. https://doi.org/10.1002/hc.520060603

    Article  Google Scholar 

  50. Huang, J. and Chen, R., Heteroat. Chem., 2000, vol. 11, p. 480. https://doi.org/10.1002/1098-1071(2000)11:7<480::

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Privolzhsky Research Medical University, Ministry of Health of the Russian Federation, 603005, Nizhny Novgorod, Russia

    A. V. Kadomtseva

  2. Alekseev Nizhny Novgorod State Technical University, 603950, Nizhny Novgorod, Russia

    G. M. Mochalov & O. V. Kuzina

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  1. A. V. Kadomtseva
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  2. G. M. Mochalov
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  3. O. V. Kuzina
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Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 6, pp. 788–801 https://doi.org/10.31857/S0514749221060021.

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Kadomtseva, A.V., Mochalov, G.M. & Kuzina, O.V. Biologically Active Coordination Compounds of Germanium. Synthesis and Physicochemical Properties. Russ J Org Chem 57, 879–888 (2021). https://doi.org/10.1134/S1070428021060026

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