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Inflammation and Limb Regeneration: The Role of the Chemokines

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Abstract

The regeneration of injured tissues is a complex physiological process. The immune system plays an indispensable role in the regeneration process and internal environment stability of damaged tissues. Heavy immune cell infiltration during wound healing stages of regeneration, aggregation of immune cells not only help to remove cell debris, but also secrete chemokines and cell growth factors. Among them, chemo-kines are the key factors in the process of regeneration, including Cys (C), Cys Cys (CC), Cys-x-Cys (CXC) and Cys-x3-Cys (CX3C) subfamilies, which are involved in regulating the migration and activation of immune cells, angiogenesis, functional changes of fibroblasts. This review focuses on the relationship among chemokines and immune cells and regenerative ability during limb regeneration, demonstrates the important contribution of chemokines in limb regeneration of salamander and explores the therapeutic potential of targeting chemokines as a new method to improve tissue regeneration.

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Funding

This work was supported by the National Natural Science Foundation of P. R. China (no. 31670996).

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Authors and Affiliations

  1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi’an, China

    Mengli Xu, Jiaojiao Su, Zhongyu Yue, Yajie Yu, Xueyi Zhao & Xin Xie

  2. GeWu Medical Research Institute (GMRI), Xi’an, China

    Xin Xie

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  1. Mengli Xu
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  2. Jiaojiao Su
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  3. Zhongyu Yue
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  4. Yajie Yu
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Correspondence to Xin Xie.

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Mengli Xu, Su, J., Yue, Z. et al. Inflammation and Limb Regeneration: The Role of the Chemokines. Russ J Dev Biol 53, 180–191 (2022). https://doi.org/10.1134/S1062360422030055

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