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Control Levels of FISH-Registered Translocations: Review of the Literature

  • RADIATION CYTOGENETICS
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Abstract—A review of the information published in the scientific literature and relating to estimation of spontaneous levels of translocations detected by various methods of FISH-staining of chromosomes in the human peripheral blood lymphocyte cultures is presented. Various authors using single, two, and three-color variants are generally indicated by a significant increase in the frequencies of these chromosome aberrations with an increase in the donor age and the absence of the influence of gender. An increase in the translocation yield was recorded for persistent smokers and, apparently, alcoholics. It was recognized as impossible to divide the effect of the race and the territorial position of research laboratories. At the same time, countries can differ significantly in terms of the lifestyle of the population, the background impact of ionizing radiation, and the medical services used, in particular, in terms of the volume of implemented radiation diagnostic research. It limits the use of spontaneous damage levels of chromosomes determined by international studies and indicates the desirability to have relevant data for individual populations. At the same time, it is necessary to state the limitation of similar information about the frequencies of translocations detected with multicolored FISH-staining in the control groups of people.

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  1. State Research Center—Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, Moscow, Russia

    E. E. Lomonosova, V. Yu. Nugis, V. A. Nikitina & M. G. Kozlova

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Lomonosova, E.E., Nugis, V.Y., Nikitina, V.A. et al. Control Levels of FISH-Registered Translocations: Review of the Literature. Biol Bull Russ Acad Sci 50, 2971–2978 (2023). https://doi.org/10.1134/S1062359023110122

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