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Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra

  • MOLECULAR BIOPHYSICS
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Abstract

The production of proteins capable of binding ice is one of the strategies evolved in biological organisms for survival in cold ecosystems where there is a risk of freezing. These proteins have an important ability to bind to the surface of ice, influence its growth and prevent cell damage and death. To understand the nature of interaction of such proteins with ice, it is necessary to know their structure. This study contributes to the understanding of the structural and dynamic mechanisms of action of ice-binding proteins that ensure the adaptation of organisms in critical conditions. The study of the contribution of proteins capable of binding ice to adaptation to cold conditions opens up wide opportunities in solving a number of important medical problems, including the development of effective cellular and organ cryoprotectants, as well as long-term storage of food products without loss of their consumer properties in the food industry.

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Funding

The research was carried out with the financial support of the Russian Science Foundation, project no. 23-24-00256.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, 630090, Novosibirsk, Russia

    G. A. Oleinik, P. Zhdanova, V. V. Koval, A. A. Chernonosov & S.V. Baranova

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    V. V. Koval

Authors
  1. G. A. Oleinik
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  2. P. Zhdanova
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  3. V. V. Koval
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  4. A. A. Chernonosov
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  5. S.V. Baranova
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Corresponding author

Correspondence to S.V. Baranova.

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The authors of this article declare that they have no conflicts of interest.

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Translated by E.Puchkov

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Abbreviations: MALDI-TOF, matrix-assisted laser desorption/ionization time-of-flight.

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Oleinik, G.A., Zhdanova, P., Koval, V.V. et al. Structure of an Ice-Binding Protein from Myoxocephalus octodecemspinosus Determined by Molecular Dynamics and Based on Circular Dichroism Spectra. BIOPHYSICS 68, 513–518 (2023). https://doi.org/10.1134/S0006350923040152

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  • DOI: https://doi.org/10.1134/S0006350923040152

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