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Ubiquitin-Proteasome System in the Regulation of Cell Pluripotency and Differentiation

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Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) demonstrate unique abilities for continuous self-renewal and differentiation into all types of somatic cells. Understanding the mechanisms controlling these properties will facilitate an effective and safe introduction of ESCs and iPSCs into cell therapy. Recent data have underscored the importance of proteostasis in the maintenance of ESC function. The present review focuses on the role of ubiquitin-proteasome system (UPS), a key member of proteostasis network, in the regulation of pluripotency and differentiation of ESCs and iPSCs.

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Funding

The work was performed with the financial support of Russian Science Foundation (grant no. 22-14-00390).

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  1. Institute of Cytology, Russian Academy of Sciences, 194064, St. Petersburg, Russia

    U. I. Podenkova, I. V. Zubarev, A. N. Tomilin & A. S. Tsimokha

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  1. U. I. Podenkova
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  2. I. V. Zubarev
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  3. A. N. Tomilin
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Contributions

U.I. Podenkova, I.V. Zubarev: writing the main part of the work, selection of literature (made an equal contribution to the preparation of the article). U.I. Podenkova and A.S. Tsimokha: preparation of illustrations. A.S. Tsimokha: selection of literature, writing a conclusion; A.N. Tomilin and A.S. Tsimokha: final edits.

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Correspondence to A. S. Tsimokha.

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Abbreviations: PSCs—pluripotent stem cells; iPSCs—induced pluripotent stem cells; UPS—ubiquitin-proteasome system; ESCs—embryonic stem cells.

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Podenkova, U.I., Zubarev, I.V., Tomilin, A.N. et al. Ubiquitin-Proteasome System in the Regulation of Cell Pluripotency and Differentiation. Cell Tiss. Biol. 17, 441–453 (2023). https://doi.org/10.1134/S1990519X23050103

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