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The Role of VEGF in Angiogenesis and Motor Recovery after Ischemic Stroke

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Abstract—Recent scientific studies indicate that angiogenesis and neurogenesis are interrelated processes that determine the functional outcome after ischemic stroke. This literature review presents current data on neurovascular interactions in ischemic stroke and describes the role of the family of vascular endothelial growth factors in the regulation of angiogenesis and neurogenesis, which play a leading role in neuronal survival and neuroplasticity. The authors searched the literature on the pathophysiological role of VEGF in acute cerebral ischemia using the relevant keywords on the PubMed and Google Scholar search engines, as well as Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, eLibrary, and other databases. Clinical studies evaluating the role of VEGF in ischemic stroke are in most cases based on animal models, and their results are ambiguous, which is determined by the versatility of its action. VEGF is an important regulator of angiogenesis, neuroprotection, and neurogenesis, but its negative effect has also been proven in the form of an increase in the permeability of the BBB and, consequently, cerebral edema, as well as the activation of inflammatory processes. Thus, further study of VEGF is needed to determine its role in functional recovery after ischemic stroke.

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REFERENCES

  1. Skvortsova, V.I., Shetova, I.M., Kakorina, E.P., Kamkin, E.G., Boiko, E.L., Alekyan, B.G., Ivanova, G.E., Shamalov, N.A., Dash’yan, V.G., and Krylov, V.V., Profilakticheskaya Meditsina, 2018, vol. 21, no. 1, pp. 4–10.

  2. Khatib, R., Arevalo, Y.A., Berendsen, M.A., Prabhakaran, S., and Huffman, M.D., Neuroepidemiology, 2018, vol. 51, pp. 104–112.

    Article  PubMed  Google Scholar 

  3. GBD 2016 Stroke Collaborators, Lancet Neurol., 2019, vol. 18, pp. 439–458.

  4. Moon, S., Chang, M.S., Koh, S.H., and Choi, Y.K., Int. J. Mol. Sci., 2021, vol. 22, p. 8543.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Schwab, M.E. and Strittmatter, S.M., Curr. Opin. Neurobiol., 2014, vol. 27, pp. 53–60.

    Article  CAS  PubMed  Google Scholar 

  6. Mahar, M. and Cavalli, V., Nat. Rev. Neurosci., 2018, vol. 19, pp. 323–337.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Tedeschi, A. and Bradke, F., Curr. Opin. Neurobiol., 2017, vol. 42, pp. 118–127.

    Article  CAS  PubMed  Google Scholar 

  8. Jung, E., Koh, S.H., Yoo, M., and Choi, Y.K., Int. J. Mol. Sci., 2020, vol. 21, p. 2273.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Namiecinska, M., Marciniak, K., and Nowak, J.Z., Postepy Hig. Med. Dosw., 2005, vol. 59, pp. 573–583.

    Google Scholar 

  10. Gora-Kupilas, K. and Josko, J., Folia Neuropathol., 2005, vol. 43, pp. 31–39.

    CAS  PubMed  Google Scholar 

  11. Cao, L., Jiao, X., Zuzga, D.S., Liu, Y., Fong, D.M., Young, D., and During, M.J., Nat. Genet., 2004, vol. 36, pp. 827–835.

    Article  CAS  PubMed  Google Scholar 

  12. Dzietko, M., Derugin, N., Wendland, M.F., Vexler, Z.S., and Ferriero, D.M., Transl. Stroke Res., 2013, vol. 4, pp. 189–200.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Nishijima, K., Ng, Y.-S., Zhong, L., Bradley, J., Schubert, W., Jo, N., Akita, J., Samuelsson, S.J., Robinson, G.S., and Adamis, A.P., Am. J. Pathol., 2007, vol. 171, pp. 53–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ma, Y., Zechariah, A., Qu, Y., and Hermann, D.M., J. Neurosci. Res., 2012, vol. 90, pp. 1873–1882.

    Article  CAS  PubMed  Google Scholar 

  15. He, Y.Z. and Lin, B., J. Clin. Orthopaed., 2012, vol. 15, pp. 569–573.

    Google Scholar 

  16. Weis, S.M. and Cheresh, D.A., Nature, 2005, vol. 437, pp. 497–504.

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Zhang, H.T., Zhang, P., Jiang, C.L., and Li, Y.L., Chin. J. Diff. Complic. Cases, 2015, vol. 14, pp. 756–758.

    CAS  Google Scholar 

  18. Marti, H.J., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., and Risau, W., Am. J. Pathol., 2000, vol. 156, pp. 965—976.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Stowe, A.M., Plautz, E.J., Nguyen, P., Frost, S.B., Eisner-Janowicz, I., Barbay, S., Dancause, N., Sensarma, A., Taylor, M.D., and Zoubina, E.V., J. Cereb. Blood Flow Metab., 2008, vol. 28, pp. 612—620.

    Article  CAS  PubMed  Google Scholar 

  20. Guan, W., Somanath, P.R., Kozak, A., Goc, A., El-Remessy, A.B., Ergul, A., Johnson, M.H., Alhusban, A., Soliman, S., and Fagan, S.C., PLoS One, 2011, vol. 6, p. 24551.

    Article  ADS  Google Scholar 

  21. Krum, J.M. and Khaibullina, A., Exp. Neurol., 2003, vol. 181, pp. 241—257.

    Article  CAS  PubMed  Google Scholar 

  22. Zhang, Z.G., Zhang, L., Tsang, W., Soltanian-Zadeh, H., Morris, D., Zhang, R., Goussev, A., Powers, C., Yeich, T., and Chopp, M., J. Cereb. Blood Flow Metab., 2002, vol. 22, pp. 379—392.

    Article  CAS  PubMed  Google Scholar 

  23. Lee, M.Y., Ju, W.K., Cha, J.H., Son, B.C., Chun, M.H., Kang, J.K., and Park, C.K., Neurosci. Let., 1999, vol. 265, pp. 107—110.

    Article  CAS  Google Scholar 

  24. Zan, L., Zhang, X., Xi, Y., Wu, H., Song, Y., Teng, G., Li, H., Qi, J., and Wang, J., Neuroscience, 2014, vol. 262, pp. 118—128.

    Article  CAS  PubMed  Google Scholar 

  25. Thau-Zuchman, O., Shohami, E., Alexandrovich, A.G., and Leker, R.R., J. Cereb. Blood Flow Metab., 2010, vol. 30, pp. 1008—1016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Manoonkitiwongsa, P.S., CNS Neurol. Disord. Drug Targets, 2011, vol. 10, pp. 215—234.

    Article  CAS  PubMed  Google Scholar 

  27. Chen, J., Zhang, C., Jiang, H., Li, Y., Zhang, L., Robin, A., Katakowski, M., Lu, M., and Chopp, M., J. Cereb. Blood Flow Metab., 2005, vol. 25, pp. 281—290.

    Article  PubMed  Google Scholar 

  28. Krum, J.M., Mani, N., and Rosenstein, J.M., Neuroscience, 2002, vol. 110, pp. 589—604.

    Article  CAS  PubMed  Google Scholar 

  29. Lee, H.J., Kim, K.S., Park, I.H., and Kim, S.U., PLoS One, 2007, vol. 2, p. 156.

    Article  ADS  Google Scholar 

  30. Ruan, G.X. and Kazlauskas, A., EMBO J., 2012, vol. 31, pp. 1692—1703.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Wu, W., Duan, Y., Ma, G., Zhou, G., Park-Windhol, C., D’Amore, P.A., and Lei, H., Investig. Ophthalmol. Vis. Sci., 2017, vol. 58, pp. 6082—6090.

    Article  CAS  Google Scholar 

  32. Guix, F.X., Uribesalgo, I., Coma, M., and Munoz, F.J., Prog. Neurobiol., 2005, vol. 76, pp. 126–152.

    Article  CAS  PubMed  Google Scholar 

  33. Geiseler, S.J. and Morland, C., Int. J. Mol. Sci., 2018, vol. 19, p. 1362.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Bauters, C., Asahara, T., Zheng, L.P., Takeshita, S., Bunting, S., Ferrara, N., Symes, J.F., and Isner, J.M., Circulation, 1995, vol. 91, pp. 2802–2809.

    Article  CAS  PubMed  Google Scholar 

  35. Ku, D.D., Zaleski, J.K., Liu, S., and Brock, T.A., Am. J. Physiol., 1993, vol. 265, pp. 586–592.

    Google Scholar 

  36. Willmot, M., Gray, L., Gibson, C., Murphy, S., and Bath, P.M., Nitric Oxide, 2005, vol. 12, pp. 141–149.

    Article  CAS  PubMed  Google Scholar 

  37. Huang, Z., Huang, P.L., Ma, J., Meng, W., Ayata, C., Fishman, M.C., and Moskowitz, M.A., J. Cereb. Blood Flow Metab., 1996, vol. 16, pp. 981–987.

    Article  CAS  PubMed  Google Scholar 

  38. Salom, J.B., Orti, M., Centeno, J.M., Torregrosa, G., and Alborch, E., Brain Res., 2000, vol. 865, pp. 149–156.

    Article  CAS  PubMed  Google Scholar 

  39. Lee, S.W., Kim, W.J., Choi, Y.K., Song, H.S., Son, M.J., Gelman, I.H., Kim, Y.J., and Kim, K.W., Nat. Med., 2003, vol. 9, pp. 900–906.

    Article  CAS  PubMed  Google Scholar 

  40. Bella, A.J., Lin, G., Tantiwongse, K., Garcia, M., Lin, C.S., Brant, W., and Lue, T.F., Part I. J. Sex. Med., 2006, vol. 3, pp. 815–820.

    Article  CAS  PubMed  Google Scholar 

  41. You, T., Bi, Y., Li, J., Zhang, M., Chen, X., Zhang, K., and Li, J., Sci. Rep., vol. 7, p. 41779.

  42. Greenberg, D.A. and Jin, K., Nature, 2005, vol. 438, pp. 954–959.

    Article  ADS  CAS  PubMed  Google Scholar 

  43. Rosenstein, J.M., Mani, N., Khaibullina, A., and Krum, J.M., J. Neurosci., 2003, vol. 23, pp. 11036–11044.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Jin, K., Mao, X.O., and Greenberg, D.A., J. Neurobiol., 2006, vol. 66, pp. 236–242.

    Article  CAS  PubMed  Google Scholar 

  45. Jin, K.L., Mao, X.O., and Greenberg, D.A., Proc. Natl. Acad. Sci. USA, 2000, vol. 97, pp. 10242–10247.

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  46. Svensson, B., Peters, M., Konig, H.G., Poppe, M., Levkau, B., Rothermundt, M., Arolt, V., Kogel, D., and Prehn, J.H., J. Cereb. Blood Flow Metab., 2002, vol. 22, pp. 1170–1175.

    Article  CAS  PubMed  Google Scholar 

  47. Hayashi, T., Abe, K., and Itoyama, Y., J. Cereb. Blood Flow Metab., 1998, vol. 18, pp. 887–895.

    Article  CAS  PubMed  Google Scholar 

  48. Bao, W.L., Lu, S.D., Wang, H., and Sun, F.Y., Zhongguo Yao Li Xue Bao, 1999, vol. 20, pp. 313–318.

    CAS  PubMed  Google Scholar 

  49. Sorrells, S.F., Paredes, M.F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K.W., James, D., Mayer, S., Chang, J., and Auguste, K.I., Nature, 2018, vol. 555, pp. 377–381.

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  50. Ming, G.-L. and Song, H., Neuron, 2011, vol. 70, pp. 687–702.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Ernst, A. and Frisen, J., PLoS Biol., 2015, vol. 13.

  52. Gage, F.H., J. Neurosci., 2002, vol. 22, pp. 612–613.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Jin, K., Wang, X., Xie, L., Mao, X.O., Zhu, W., Wang, Y., Shen, J., Mao, Y., Banwait, S., and Greenberg, D.A., Proc. Natl. Acad. Sci. USA, 2006, vol. 103, pp. 13198–13202.

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  54. Wang, Y.Q., Cui, H.R., Yang, S.Z., Sun, H.P., Qiu, M.H., Feng, X.Y., and Sun, F.Y., Neurochem. Int., 2009, vol. 55, pp. 629–636.

    Article  CAS  PubMed  Google Scholar 

  55. Wang, Y., Jin, K., Mao, X.O., Xie, L., Banwait, S., Marti, H.H., and Greenberg, D.A., J. Neurosci. Res., 2007, vol. 85, pp. 740–747.

    Article  CAS  PubMed  Google Scholar 

  56. Kirby, E.D., Kuwahara, A.A., Messer, R.L., and Wyss-Coray, T., Proc. Natl. Acad. Sci. USA, 2015, vol. 112, pp. 4128–4133.

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  57. Li, W.-L., Fraser, J.L., Yu, S.P., Zhu, J., Jiang, Y.-J., and Wei, L., Exp. Brain Res., 2011, vol. 214, p. 503.

    Article  CAS  PubMed  Google Scholar 

  58. Schanzer, A., Wachs, F.P., Wilhelm, D., Acker, T., Cooper-Kuhn, C., Beck, H., Winkler, J., Aigner, L., Plate, K.H., and Kuhn, H.G., Brain Pathol., 2004, vol. 14, pp. 237–248.

    Article  PubMed  Google Scholar 

  59. Matsuo, R., Ago, T., Kamouchi, M., Kuroda, J., Kuwashiro, T., Hata, J., Sugimori, H., Fukuda, K., Gotoh, S., and Makihara, N., BMC Neurol., 2013, vol. 13, p. 32.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Seidkhani-Nahal, A., Khosravi, A., and Mirzaei, A., Neurol. Sci., 2021, pp. 1811–1820.

  61. Lee, S.C., Lee, K.Y., Kim, Y.J., Kim, S.H., Koh, S.H., and Lee, Y.J., Eur. J. Neurol., 2010, vol. 17, no. 1, pp. 45–51.

    Article  PubMed  Google Scholar 

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  1. Siberian State Medical University, Tomsk, Russia

    K. S. Kucherova, E. S. Koroleva & V. M. Alifirova

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  1. K. S. Kucherova
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Kucherova, K.S., Koroleva, E.S. & Alifirova, V.M. The Role of VEGF in Angiogenesis and Motor Recovery after Ischemic Stroke. Neurochem. J. 17, 528–533 (2023). https://doi.org/10.1134/S1819712423040141

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