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Synergic Synthesis and Characterization of tert-Butyl 4-[(E)-But-1-en-3-yn-1-yl]-3-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate

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Abstract

tert-Butyl 4-[(E)-but-1-en-3-yn-1-yl]-3-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate has been synthesized with a good yield and selectivity starting from commercially available 4-bromo-1H-indole and using simple reagents. The title compound is a potential precursor to biologically active natural products like Indiacen A and Indiacen B. The newly synthesized compounds were characterized by spectral data.

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ACKNOWLEDGMENTS

The authors are thankful to Management and Principal, Sreenidhi Institute of Science and Technology, Hyderabad, India for providing necessary facilities to carry out this work.

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Authors and Affiliations

  1. Sreenidhi Institute of Science and Technology (Autonomous), Yamnampet, Ghatkesar, 501301, Hyderabad, Telangana, India

    B. Ravi Kumar & E. Laxminarayana

  2. Jawaharlal Nehru Technological University Hyderabad, Kukatpally, 500085, Hyderabad, Telangana, India

    A. Kishore Kumar

  3. Mahatma Gandhi Institute of Technology, Gandipet, 500075, Hyderabad, Telangana, India

    B. Srinivas Reddy

  4. Geethanjali College of Engineering and Technology (Autonomous), Cheeryal, Keesara, 501301, Hyderabad, Telangana, India

    K. Shashikala

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  1. B. Ravi Kumar
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  2. A. Kishore Kumar
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  3. B. Srinivas Reddy
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  4. K. Shashikala
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  5. E. Laxminarayana
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Correspondence to E. Laxminarayana.

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Kumar, B.R., Kumar, A.K., Reddy, B.S. et al. Synergic Synthesis and Characterization of tert-Butyl 4-[(E)-But-1-en-3-yn-1-yl]-3-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate. Russ J Org Chem 58, 580–583 (2022). https://doi.org/10.1134/S1070428022040169

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