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Efficient Synthesis of Pyrido[2,3-d]pyrimidines by Recyclization of N-Arylitaconimides with Aminopyrimidinones

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Abstract

A convenient method has been proposed for the synthesis of 2-(4,7-dioxopyrido[2,3-d]pyrimidin-6-yl)acetanilides and 2-(2,4,7-trioxopyrido[2,3-d]pyrimidin-6-yl)acetanilides via reaction of N-arylitaconimides with 6-aminopyrimidin-4(3H)-ones and 6-aminopyrimidine-2,4(1H,3H)-diones, respectively, in boiling acetic acid.

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ACKNOWLEDGMENTS

The IR and mass spectra were recorded using the facilities of the Joint Scientific Equipment Center at the Voronezh State University.

Funding

This study was performed under financial support by the Ministry of Science and Higher Education of the Russian Federation in the framework of state assignment for higher education institutions in the sphere of research activity for 2020–2022 (project no. FZGU-2020-0044).

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Authors and Affiliations

  1. Voronezh State University, 394018, Voronezh, Russia

    Y. U. Shmoylova, Yu. A. Kovygin, D. Yu. Vandyshev, I. V. Ledenyova, E. A. Kosheleva & Kh. S. Shikhaliev

Authors
  1. Y. U. Shmoylova
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  2. Yu. A. Kovygin
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  3. D. Yu. Vandyshev
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  4. I. V. Ledenyova
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  5. E. A. Kosheleva
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  6. Kh. S. Shikhaliev
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Corresponding author

Correspondence to Kh. S. Shikhaliev.

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Shmoylova, Y.U., Kovygin, Y.A., Vandyshev, D.Y. et al. Efficient Synthesis of Pyrido[2,3-d]pyrimidines by Recyclization of N-Arylitaconimides with Aminopyrimidinones. Russ J Org Chem 56, 1512–1518 (2020). https://doi.org/10.1134/S107042802009002X

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  • DOI: https://doi.org/10.1134/S107042802009002X

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