Abstract
Nanosuspension of betamethasone dipropionate (BD), an insoluble glucocorticoid drug, was prepared using the medium grinding method, and the process parameters were screened through single factor experiment. Physicochemical characteristics of the prepared BD nanosuspension were studied by scanning electron microscopy, differential scanning calorimetry and powder X-ray scattering techniques. Pharmacodynamic evaluation was conducted on a psoriasis mouse model, and BD nanosuspension showed significant and excellent effects (significantly superior to MTX positive control drugs and physical mixtures in terms of PASI score and histopathological improvement of mouse skin lesions).
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ACKNOWLEDGMENTS
The authors thank the management of Changzhou Siyao Co., Ltd. for providing all the necessary facilities for sample preparation. We would also like to thank Nanjing University of Traditional Chinese Medicine for providing experimental and analytical support for the pharmacodynamic evaluation of the samples. The authors would like to thank Yanbo times (www.yanbotimes.cn) for the support of TGA and DSC.
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The studies were performed in accordance with all applicable international, national and institutional guidelines for the care and use of animals. The authors declare no conflict of interest.
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Shen, Z., Chen, J., Liu, M. et al. Preparation, Physicochemical Characterization, and Pharmacodynamic Study of Betamethasone Dipropionate Nanosuspension. Russ J Gen Chem 93, 2113–2122 (2023). https://doi.org/10.1134/S1070363223080200
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DOI: https://doi.org/10.1134/S1070363223080200