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Multilayer Coatings Based On Citrate-Stabilized Gold Nanoparticles and Polydiallyldimethylammonium Chloride for the Electrophoretic Separation of Carboxylic Acids

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Abstract

The conditions for the formation of physically adsorbed three-layer coatings of quartz capillary walls in capillary electrophoresis (CE) with successively deposited oppositely charged layers of polydiallyldimethylammonium chloride (PDADMAC) modifiers and citrate-stabilized gold nanoparticles (GNPs) are proposed. It was shown that three-layer PDADMAC–GNP–PDADMAC coatings favorably differ from monolayer coatings with PDADMAC by greater stability in a wide range of pH (2–10). The formed coatings were characterized by scanning electron microscopy, and the presence of a uniform dense layer of nanoparticles on the capillary surface was confirmed. The applicability of the modified capillaries under CE conditions was demonstrated by the separation of a mixture of 16 carboxylic acids. An increase in the separation selectivity achieved with the use of three-layer coatings based on GNPs was explained by the reversible exchange of citrate anions on the GNP surface with negatively charged analytes in the course of electrophoretic analysis.

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ACKNOWLEDGMENTS

We are grateful to the Resource Center “Methods for Analyzing the Composition of Substances” for the opportunity to perform capillary electrophoresis studies and to the Interdisciplinary Resource Center “Nanotechnology” (Science Park at St. Petersburg State University) for performing scanning and transmission electron microscopy analysis.

Funding

This study was supported by the Russian Science Foundation (grant no. 21-73-00211, https://rscf.ru/project/21-73-00211).

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Authors and Affiliations

  1. St. Petersburg State University, 199034, St. Petersburg, Russia

    D. V. Makeeva, K. S. Antipova, E. V. Solovyeva, V. P. Morgacheva, E. A. Kolobova & L. A. Kartsova

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  1. D. V. Makeeva
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  2. K. S. Antipova
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  3. E. V. Solovyeva
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  4. V. P. Morgacheva
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  5. E. A. Kolobova
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  6. L. A. Kartsova
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Corresponding author

Correspondence to D. V. Makeeva.

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The authors declare that they have no conflicts of interest.

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Translated by V. Makhlyarchuk

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Makeeva, D.V., Antipova, K.S., Solovyeva, E.V. et al. Multilayer Coatings Based On Citrate-Stabilized Gold Nanoparticles and Polydiallyldimethylammonium Chloride for the Electrophoretic Separation of Carboxylic Acids. J Anal Chem 78, 361–371 (2023). https://doi.org/10.1134/S1061934823030085

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  • DOI: https://doi.org/10.1134/S1061934823030085

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