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Etoposide-Loaded Colloidal Delivery Systems Based on Biodegradable Polymeric Carriers

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The review is focused on the etoposide delivery systems based on colloidal carriers, i.e., nanoparticles and micelles made of synthetic and natural polymers. Etoposide, a topoisomerase II inhibitor, occupies an important place in the chemotherapy of a number of tumors; however, its use is often limited due to severe side effects. The application of colloidal delivery systems makes it possible to change the pharmacokinetic parameters of etoposide and increase its accumulation in tumors leading to an increase in the antitumor effect. Of particular interest are stimuli-sensitive systems that respond to specific conditions in the tumor microenvironment, which can significantly increase the selectivity of the drug.

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The work was supported by the Russian Science Foundation (project no. 23-25-00194).

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  1. Mendeleev University of Chemical Technology of Russia, 125047, Moscow, Russia

    M. A. Merkulova, N. S. Osipova, A. V. Kalistratova, Yu. V. Ermolenko & S. E. Gel’perina

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Merkulova, M.A., Osipova, N.S., Kalistratova, A.V. et al. Etoposide-Loaded Colloidal Delivery Systems Based on Biodegradable Polymeric Carriers. Colloid J 85, 712–735 (2023). https://doi.org/10.1134/S1061933X23600744

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