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Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine

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Abstract

Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acylation of various amines to yield the corresponding diamides. Reaction of [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine with chlorides of N-substituted p-aminobenzoic acids has led to formation of diamides.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Institute of Fine Organic Chemistry, ave. Azatutyan 26, Yerevan, 0014, Armenia

    A. A. Agekyan & G. G. Mkryan

Authors
  1. A. A. Agekyan
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  2. G. G. Mkryan
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Correspondence to A. A. Agekyan.

Additional information

Original Russian Text © A.A. Agekyan, G.G. Mkryan, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 5, pp. 760–764.

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Agekyan, A.A., Mkryan, G.G. Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine. Russ J Gen Chem 85, 1057–1062 (2015). https://doi.org/10.1134/S1070363215050096

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  • DOI: https://doi.org/10.1134/S1070363215050096

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