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Characteristics of disturbances of intercortical and cortical-subcortical integration in various clinical forms of neurotic depression

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Abstract

Cross-correlation, coherent, and factor analyses of the EEG were used to detect disturbances of spatial organization of brain bioelectric activity, with certain specific features determined by concomitant anxiety and asthenia syndromes in 20 patients with various clinical forms of neurotic depression. In the group of patients with dominance of the depressive syndrome without marked symptoms of asthenia or anxiety, opposite changes in the anterior areas of the right and left hemispheres were found; the interregional relationships of the EEG of anterior areas of the right hemisphere were decreased as compared to the norm, while the normal level of systemic interaction of bioelectric potentials of the cortex of the left hemisphere was increased. In patients with the depressive syndrome combined with increased anxiety, as well as in patients with distinct asthenic symptoms, a considerable decrease in the level of interregional interactions of bioelectric potentials in frontal regions of the cortex of both hemispheres was detected. This was accompanied by an increase, as compared to the norm, of the level of distant relationships of the EEG in posterotemporal, parietal, and occipital regions. The data indicate that, in the case of neurotic depression, irrespective of concomitant anxiety and asthenia syndromes, there is transient inhibition of the functional activity of frontal regions along with an increased rigidity of systemic interactions of the posterior regions of the cortex of both hemispheres. This suggests that neurotic depression is accompanied by dysfunction of intercortical and cortical-subcortical integration, which causes a disturbance of the systemic organization of ordered interactions of the activity of the anterior and posterior regions of both hemispheres, with certain specific features in patients of each group.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia

    A. A. Ivonin, D. O. Kutsenko, A. M. Shchepina, V. V. Titova & V. T. Shuvaev

  2. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia

    M. N. Tsitseroshin

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  1. A. A. Ivonin
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  2. M. N. Tsitseroshin
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  3. D. O. Kutsenko
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  4. A. M. Shchepina
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  5. V. V. Titova
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  6. V. T. Shuvaev
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Original Russian Text © A.A. Ivonin, M.N. Tsitseroshin, D.O. Kutsenko, A.M. Shchepina, V.V. Titova, V.T. Shuvaev, 2008, published in Fiziologiya Cheloveka, 2008, Vol. 34, No. 6, pp. 10–22.

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Ivonin, A.A., Tsitseroshin, M.N., Kutsenko, D.O. et al. Characteristics of disturbances of intercortical and cortical-subcortical integration in various clinical forms of neurotic depression. Hum Physiol 34, 660–671 (2008). https://doi.org/10.1134/S0362119708060029

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