Abstract
New potential inhibitors of 5-lipoxygenase (5-LOX) based on the structure of 2-(3-benzoylphenyl)propanoic acid (an active component of the nonsteroidal antiinflammatory drug Ketoprofen) were designed using the SARD-21 program. The docking of these compounds in the active site of 5-LOX suggested that seven compounds can interact with this enzyme. Two of them can also be dual inhibitors of 5-LOX and two isoforms of cyclooxygenase.
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Original Russian Text © V. R. Khayrullina, I. A. Taipov, A. V. Veselovsky, D. S. Shcherbinin, A. Ya. Gerchikov, 2014, published in Biokhimiya, 2014, Vol. 79, No. 4, pp. 476–484.
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Khayrullina, V.R., Taipov, I.A., Veselovsky, A.V. et al. New inhibitors of 5-lipoxygenase catalytic activity based on 2-(3-methylphenyl)propanoic acid and 4-substituted morpholine derivatives. Biochemistry Moscow 79, 376–384 (2014). https://doi.org/10.1134/S0006297914040063
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DOI: https://doi.org/10.1134/S0006297914040063