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Number of Ouabain-binding Sites in Fibroblasts from Normal Subjects and Patients with Cystic Fibrosis

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Abstract

ONE of the characteristics of cystic fibrosis (CF), an autosomal recessive disease, is a defect in the net sodium transport in the eccrine glands resulting in an increased concentration of sodium in the sweat1. This defect has yet to be characterised as an extrinsic and/or intrinsic phenomenon. Mangos and McSherry2 demonstrated an unidentified factor in the sweat from CF patients which inhibited sodium reabsorption in the rat parotid duct after retrograde perfusion. The relationship of the sweat factor to factors observed in saliva3 and sera4,5 of CF patients has yet to be elucidated.

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References

  1. Sant' Agnese, P. A., and Talamo, R. C., New Engl. J. Med., 277, 1344 (1967).

    Article  Google Scholar 

  2. Mangos, J. A., and McSherry, N. R., Science, N.Y., 158, 135 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Mangos, J. A., McSherry, N. R., and Benke, P. J., Pediat. Res., 1, 436 (1967).

    Article  CAS  Google Scholar 

  4. Spock, A., Heick, H. M. C., Cress, H., and Logan, W. S., Pediat. Res., 1, 173 (1967).

    Article  CAS  Google Scholar 

  5. Bowman, B. H., McCombs, M. L., and Lockhart, L. H., Science, NY, 167, 869 (1970).

    Article  ADS  Google Scholar 

  6. Balfe, J., Cole, C., and Welt, L., Science, N.Y., 162, 689 (1968).

    Article  ADS  CAS  Google Scholar 

  7. Lapey, A., and Gardner, J., Pediat. Res., 4, 478 (1970).

    Article  Google Scholar 

  8. Horton, C., Cole, W., and Bader, H., Biochem. biophys. Res. Commun., 40, 505 (1970).

    Article  CAS  Google Scholar 

  9. Fitzpatrick, D., Landon, E., and James, V., Nature new Biol., 235, 173 (1969).

    Article  Google Scholar 

  10. Hadden, J. W., Hansen, L. G., Shapiro, B. L., and Warwick, W. J., Proc. Soc. exp. Biol. Med., 142, 577 (1973).

    Article  CAS  Google Scholar 

  11. Baker, P. F., and Willis, J. S., Biochim. biophys. Acta, 183, 646 (1969).

    Article  CAS  Google Scholar 

  12. Hoffman, J. F., J. gen. Physiol., 54, 343 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Ellory, J. C., and Keynes, R. D., Nature, 221, 776 (1969).

    Article  ADS  CAS  Google Scholar 

  14. Lamb, J. F., and McCall, D., J. Physiol., 213, 57P (1971).

    CAS  PubMed  Google Scholar 

  15. Baker, P. F., and Willis, J. S., J. Physiol., 244, 441 (1972).

    Article  Google Scholar 

  16. Boardman, L. J., Lambd, J. F., and McCall, D., J. Physiol., 225, 619 (1972).

    Article  CAS  Google Scholar 

  17. Bowman, B. H., Barnett, D. R., Matalon, R., Danes, B. S., and Bearn, A. G., Proc. natn. Acad. Sci., 70, 548 (1973).

    Article  ADS  CAS  Google Scholar 

  18. Fletcher, D. S., and Lin, T. Y., Clin. Chim. Acta, 44, 5 (1973).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Pathology and Oncology, University of Wisconsin, The Medical School, Madison, Wisconsin, 53706

    D. O. QUISSELL & H. C. PITOT

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  1. D. O. QUISSELL
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  2. H. C. PITOT
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QUISSELL, D., PITOT, H. Number of Ouabain-binding Sites in Fibroblasts from Normal Subjects and Patients with Cystic Fibrosis. Nature 247, 115–116 (1974). https://doi.org/10.1038/247115a0

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  • DOI: https://doi.org/10.1038/247115a0

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