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Lysosomes, pH and the Anti-malarial Action of Chloroquine

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Abstract

MALARIA parasites1 or mammalian liver2 suitably exposed to chloroquine rapidly form autophagic vacuoles; in the case of the parasites, these are visible under the light microscope because they contain clumps of pigment, the remains of haemoglobin digestion (Fig. 1). These striking morphological changes are well known but not correspondingly well understood.

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Author notes

  1. C. A. HOMEWOOD and D. C. WARHURST: MRC Research Group on the Chemotherapy of Protozoal Diseases and Drug Resistance.

Authors and Affiliations

  1. Department of Parasitology, Liverpool School of Tropical Medicine,

    C. A. HOMEWOOD, D. C. WARHURST, W. PETERS & V. C. BAGGALEY

Authors
  1. C. A. HOMEWOOD
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  2. D. C. WARHURST
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  3. W. PETERS
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  4. V. C. BAGGALEY
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HOMEWOOD, C., WARHURST, D., PETERS, W. et al. Lysosomes, pH and the Anti-malarial Action of Chloroquine. Nature 235, 50–52 (1972). https://doi.org/10.1038/235050a0

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  • DOI: https://doi.org/10.1038/235050a0

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