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Microinjection of Ouabain into Crab Muscle Fibres

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Abstract

CARDIAC glycosides potentiate the contraction of cardiac muscle, but not skeletal muscle1. This difference may be a matter of cell penetration rather than muscular mechanism: to investigate this point we have microinjected ouabain into crab skeletal muscle fibres. In this article we report that ouabain, when applied intracellularly, potentiates the contraction of skeletal muscle.

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Authors and Affiliations

  1. Pharmacological Department, Sapporo Medical College, Sapporo, Japan

    SUMIKO FUJINO & MAMORU TANAKA

  2. Physiological Department, Sapporo Medical College, Sapporo, Japan

    MASAHIRO FUJINO

Authors
  1. SUMIKO FUJINO
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  2. MAMORU TANAKA
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  3. MASAHIRO FUJINO
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FUJINO, S., TANAKA, M. & FUJINO, M. Microinjection of Ouabain into Crab Muscle Fibres. Nature 223, 413–414 (1969). https://doi.org/10.1038/223413a0

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  • DOI: https://doi.org/10.1038/223413a0

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