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Effect of Carnosine on Drosophila Melanogaster Lifespan

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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A positive dose-dependent effect of carnosine (beta-alanyl-L-histidine) on the lifespan of male Drosophila melanogaster flies was shown. The mean lifespan of male flies receiving 200 mg/liter carnosine approached that of females. At the same time carnosine had no effect on the lifespan of female flies. This positive effect of carnosine probably reflects its protective action against age-related accumulation of free radicals and did not depend on carnosine metabolism in the body. Addition of 200 mg/liter histidine and beta-alanine (separately or in combination) had no effect on the mean lifespan of flies.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Russia

    A. O. Yuneva, G. G. Kramarenko, T. V. Vetreshchak, S. Gallant & A. A. Boldyrev

  2. Institute of Neurology, Russian Academy of Medical Sciences, Moscow

    A. O. Yuneva, G. G. Kramarenko, T. V. Vetreshchak & A. A. Boldyrev

  3. Zoetic Neurosciences Ltd., Luton, Great Britain

    A. O. Yuneva, G. G. Kramarenko, T. V. Vetreshchak & A. A. Boldyrev

Authors
  1. A. O. Yuneva
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  2. G. G. Kramarenko
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  3. T. V. Vetreshchak
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  4. S. Gallant
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  5. A. A. Boldyrev
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Yuneva, A.O., Kramarenko, G.G., Vetreshchak, T.V. et al. Effect of Carnosine on Drosophila Melanogaster Lifespan. Bulletin of Experimental Biology and Medicine 133, 559–561 (2002). https://doi.org/10.1023/A:1020273506970

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  • DOI: https://doi.org/10.1023/A:1020273506970

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