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Biphasic calcium phosphate bioceramics: preparation, properties and applications

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Abstract

Biphasic calcium phosphate (BCP) bioceramics belong to a group of bone substitute biomaterials that consist of an intimate mixture of hydroxyapatite (HA), Ca10(PO4)6(OH)2, and beta-tricalcium phosphate (β-TCP), Ca3(PO4)2, of varying HA/β-TCP ratios. BCP is obtained when a synthetic or biologic calcium-deficient apatite is sintered at temperatures at and above 700 °C. Calcium deficiency depends on the method of preparation (precipitation, hydrolysis or mechanical mixture) including reaction pH and temperature. The HA/β-TCP ratio is determined by the calcium deficiency of the unsintered apatite (the higher the deficiency, the lower the ratio) and the sintering temperature. Properties of BCP bioceramics relating to their medical applications include: macroporosity, microporosity, compressive strength, bioreactivity (associated with formation of carbonate hydroxyapatite on ceramic surfaces in vitro and in vivo), dissolution, and osteoconductivity. Due to the preferential dissolution of the β-TCP component, the bioreactivity is inversely proportional to the HA/β-TCP ratio. Hence, the bioreactivity of BCP bioceramics can be controled by manipulating the composition (HA/β-TCP ratio) and/or the crystallinity of the BCP. Currently, BCP bioceramics is recommended for use as an alternative or additive to autogeneous bone for orthopedic and dental applications. It is available in the form of particulates, blocks, customized designs for specific applications and as an injectible biomaterial in a polymer carrier. BCP ceramic can be used also as grit-blasting abrasive for grit-blasting to modify implant substrate surfaces. Exploratory studies demonstrate the potential uses of BCP ceramic as scaffold for tissue engineering, drug delivery system and carrier of growth factors.

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References

  1. F. H. Albee, Ann. Surg. 71 (1920) 32.

    Google Scholar 

  2. E. B. Nery, K. L. Lynch and W. M. Hirthe, J. Periodontol. 63 (1975) 729.

    Google Scholar 

  3. H. W. Denissen, PhD Thesis, Amsterdam, Vrije Universiteit (1979).

  4. M. Jarcho, Clin. Orthop. 157 (1981) 259.

    Google Scholar 

  5. K. Degroot, “Bioceramics of Calcium Phosphate” (CRC Press, Boca Raton, 1983).

    Google Scholar 

  6. S. D. Metsger, T. D. Driskell and J. R. Paulsrud, J. Am. Dent. Assoc. 105 (1982) 1035.

    Google Scholar 

  7. H. Aoki and K. Kato, Jpn. Ceram. Soc. 10 (1975) 469.

    Google Scholar 

  8. R. Z. Legeros, Adv. Dent. Res. 3 (1988) 164.

    Google Scholar 

  9. R. F. Ellinger, E. B. Nery and K. L. Lynch, J. Periodont. Restor. Dent. 3 (1986) 223.

    Google Scholar 

  10. E. B. Nery, K. K. Lee and S. Czajkowski, J. Periodontol. 61 (1990) 737.

    Google Scholar 

  11. R. Z. Legeros, E. Nery, G. Daculsi, K. Lynch and B. Kerebel, “Third World Biomaterials Congress” (1988) abstract 35.

  12. R. Z. Legeros and G. Daculsi, in “CRC Handbook of Bioactive Ceramics”, edited by T. Yamamuro, L. Hench and J. Wilson-Hench (CRC Press, Boca Raton, 1990) p. 17.

    Google Scholar 

  13. G. Daculsi, R. Z. Legeros, E. Nery, K. Lynch and B. Kerebel, J. Biomed. Mater. Res. 23 (1989) 883.

    Google Scholar 

  14. E. B. Nery, R. Z. Legeros, K. L. Lynch and J. Kalbfleisch, J. Periodontol. 63 (1992) 729.

    Google Scholar 

  15. G. Daculsi and N. Passuti, Biomaterials 11 (1990) 86.

    Google Scholar 

  16. G. Daculsi, N. Passuti, S. Martin, C. Deudon and R. Z. Legeros, J. Biomed. Mater. Res. 24 (1990) 379.

    Google Scholar 

  17. G. Daculsi, M. Bagot D'Arc, P. Corlieu and M. Gersdorff, Ann. Orol. Rhinol. Laryngol. 101 (1992) 669.

    Google Scholar 

  18. M. Trecant, J. Delecrin, J. Royer, E. Goyenvalle and G. Daculsi, Clin. Mater. 15 (1994) 233.

    Google Scholar 

  19. F. Gouin, J. Delecrin, N. Passuti, S. Touchais, P. Poirier and J. V. Bainvel, Chir. Orthop. 81 (1995) 59.

    Google Scholar 

  20. Ransford, N. Passuti, D. Chopin and C. Morin, J. Bone Joint Surg. Br. 80 (1998) 13.

    Google Scholar 

  21. R. Ravagna, G. Daculsi, J.-M. Bouler, J. Longterm Effects Med. Impl. 9 (1999) 403.

    Google Scholar 

  22. R. E. Grundel, M. W. Chapman, T. Yee and D. C. Moore, Clin. Orthop. Rel. Res. 256 (1991) 256.

    Google Scholar 

  23. M. Basle, D. Chappard, F. Grizon, R. Filmon, G. Daculsi and A. Rebel, Calcif. Tissue Int. 53 (1993) 348.

    Google Scholar 

  24. O. Gauthier, J.-M. Bouler, E. Aguado, P. Pilet and G. Daculsi, Biomaterials 19 (1998) 133.

    Google Scholar 

  25. M. Hashimoto-Uoshima, I. Ishikawa, A. Kinoshita, H. T. Weng and S. Oda, Int. J. Periodont. Res. Dent. 15 (1995) 204.

    Google Scholar 

  26. E. J. C. Soares, V. P. Franca, L. Wykrota and S. Stumpf, in “Bioceramics 11”, edited by R. Z. LeGeros and J. P. LeGeros (World Scientific, Singapore, 1998) p. 633.

    Google Scholar 

  27. L. L. Wykrota, C. A. Garrido and F. H. I. Wykrota, in “Bioceramics 11”, edited by R. Z. LeGeros and J. P. LeGeros (Singapore, World Scientific 1998) p. 641.

    Google Scholar 

  28. R. Z. Legeros, Prog. Crystal Growth Charact. 4 (1981) 1.

    Google Scholar 

  29. R. Z. Legeros, “Calcium Phosphates in Oral Biology and Medicine”, Monograph in Oral Science, Vol. 15 (Karger, Basel, 1991).

    Google Scholar 

  30. R. Z. Legeros, D. Lee, G. Quirolgico and W. P. Shirra, Scan. Electron Microscop. 3 (1983) 407.

    Google Scholar 

  31. J. M. Bouler, R. Z. Legeros and G. Daculsi, J. Biomed. Mater. Res. 51 (2000) 680.

    Google Scholar 

  32. R. Z. Legeros, J. P. Legeros, O. R. Trautz and W. P. Shirra, Adv X-ray Anal 14 (1971) 57.

    Google Scholar 

  33. R. Z. Legeros, I. Orly and G. Daculsi, Scan. Electron Microscop. 3 (1989) 129.

    Google Scholar 

  34. J.-M. Bouler, M. Trecant, J. Delecrin, J. Royer, N. Passuti and G. Daculsi, J. Biomed. Mater. Res. 32 (1996) 603.

    Google Scholar 

  35. R. Z. Legeros, J. Dent. Res. 65 (1986) 292.

    Google Scholar 

  36. R. Z. Legeros, R. Zheng, R. Kijkowska, D. Fan and J. P. Legeros, in “Characterization and Performance of Calcium Phosphate Coatings for Implants”, edited by E. Horowitz, J. E. Parr (American Society for Testing Materials STP 1198, Philadelphia, 1994) p. 43.

    Google Scholar 

  37. R. Z. Legeros, T. Sakae, C. Bautista, M. Retino and J. P. Legeros, Adv. Dent. Res. 10 (1996) 252.

    Google Scholar 

  38. O. Gauthier, J. M. Bouler, E. Aguado, R. Z. Legeros, P. Pilet and G. Daculsi, J. Mat. Sci: Mat. Med. 10 (1999) 199-204.

    Google Scholar 

  39. D. Fan, R. Z. Legeros and J. P. Legeros, J. Dent. Res. 74 (1995) 525.

    Google Scholar 

  40. W. G. Hubbard, PhD Thesis, Milwaukee, Marquette University (1974).

  41. M. Schmitt, PhD Thesis, Nantes, Universite de Nantes (2000).

  42. A. A. Driessen, C. P. A. T. Klein and De Groot, Biomaterials 3 (1982) 113.

    Google Scholar 

  43. R. Rohanizadeh, M. Padrines, J. M. Bouler, D. Couchourel, Y. Fortun and G. Daculsi, J. Biomed. Mater. Res. 42 (1998) 530.

    Google Scholar 

  44. J. J. Klawitter and S. F. Hulbert, J. Biomed. Mater. Res. 2 (1971) 161.

    Google Scholar 

  45. P. S. Eggli, W. Muller and R. K. Schenk, Clin. Orthop. 232 (1988) 127.

    Google Scholar 

  46. A. Ravaglioli, A. Krajewski, “Bioceramics: Materials, Properties, Applications” (Chapman and Hall, London, 1992) p. 432

    Google Scholar 

  47. R. Z. Legeros, Clin. Mater. 14 (1993) 65.

    Google Scholar 

  48. A. Soueidan, O. I. Gan, J. M. Bouler, F. Gouin and G. Daculsi, Cells Mater. 5 (1995) 31.

    Google Scholar 

  49. M. Benahmed, J. M. Bouler, D. Heymann, O. Gan and G. Daculsi, Biomaterials 17 (1996) 2173.

    Google Scholar 

  50. S. Yamada, D. Heymann, J.-M. Bouler and G. Daculsi, ibid. 18 (1997) 1037.

    Google Scholar 

  51. Y. L. Chang, C. M. Stanford and J. C. Keller, J. Biomed. Mater. Res. 52 (2000) 270.

    Google Scholar 

  52. L. L. Hench, Am. Ceram. Soc. Bull. 72 (1993) 93.

    Google Scholar 

  53. J. F. Osborn and H. Newesely, Biomaterials 1 (1980) 108.

    Google Scholar 

  54. G. Daculsi, R. Z. Legeros and C. Deudon, Scan. Electron Microscop. 4 (1990) 309.

    Google Scholar 

  55. T. Kokubo, Thermochim. Acta 280 (1996) 479.

    Google Scholar 

  56. R. Z. Legeros, I. Orly, M. Gregoire and G. Daculsi, in “The Bone-Biomaterial Interface”, edited by J. E. Davies (1991) p. 76.

  57. M. Heughebaert, R. Z. Legeros and M. Gineste, J. Biomed. Mater. Res. 22 (1988) 257.

    Google Scholar 

  58. R. Rohanizadeh, M. Trecant-Viana and G. Daculsi, Calcif. Tissue Int. 64 (1999) 430.

    Google Scholar 

  59. H. T. Weng, M. Uoahima and C. T. Lin, Dent. Jpn. 28 (1991) 155.

    Google Scholar 

  60. R. Z. Legeros, Clin. Orthopaed. Rel. Res. (in press).

  61. M. R. Urist, Science 150 (1965) 893.

    Google Scholar 

  62. R. A. Kenley, K. Yim, J. Abrams, E. Ron, T. Turek, L. J. Marden and J. O. Hollinger, Pharmaceut. Res. 10 (1993) 1393.

    Google Scholar 

  63. A. H. Reddi, Tissue Eng. 6 (2000) 351.

    Google Scholar 

  64. J. M. Toth, K. L. Lynch and D. A. Hackbarth, Bioceramics 6 (1993) 9.

    Google Scholar 

  65. Y. Kuboki, H. Takita and D. Kobayashi, J. Biomed. Mater. Res. 39 (1998) 190.

    Google Scholar 

  66. U. Ripamonti, S. Ma and A. H. Reddi, Matrix 12 (1992) 202.

    Google Scholar 

  67. G. Daculsi, Biomaterials 19 (1998) 1473.

    Google Scholar 

  68. P. Weiss, M. Lapkowski, R. Z. Legeros, J. M. Bouler, A. Jean and G. Daculsi, J. Mat. Sci. Mat. Med. 8 (1997) 621.

    Google Scholar 

  69. G. Daculsi, P. Weiss, J. Delacrin, G. Grimandi, N. Passuti and F. Guerin, Patent no. 94-01-414 (1994) France.

  70. K. Suzuki, M. Yamada, K. Yamamoto and T. Tanaka, in “Bioceramics 11”, edited by R. Z. LeGeros, J. P. LeGeros (World Scientific Singapore, 1998) 629.

    Google Scholar 

  71. T. Salgado, J. P. Legeros and J. Wang, in “Bioceramics 11”, edited by R. Z. LeGeros, J. P. LeGeros (World Scientific Singapore, 1998) 683.

    Google Scholar 

  72. M. I. Alam, I. Asahina, K. Ohmmaiuda and S. Enomoto, J. Biomed. Mater. Res. 54 (2000) 129.

    Google Scholar 

  73. O. Gauthier, J. Guicheux, G. R Grimandi, A. Faivre-Cahuvet and G. Daculsi, ibid. 40 (1998) 606.

    Google Scholar 

  74. S. P. Bruder, N. Jaiswal, N. S. Ricalton, J. D. Mosca, K. H. Kraus and S. Kadiyala, Clin Orthop. 355 (1998) S247-56.

    Google Scholar 

  75. H. Ohgushi and Kaplan, J. Biomed. Mater. Res. Appl. Biomater. 48 (1999) 913.

    Google Scholar 

  76. S. Gronthos, M. Mankani, J. Brahim, P. Gehron Robey and S. Shi, PNAS 97(25) (2000) 13625

    Google Scholar 

  77. G. Daculsi, O. Gauthier, P. Pilet, C. Gobin, S. Kadilaya and T. Linvingstone, in “14th European Conference on Biomaterials” (London, UK, 2001).

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  1. Department of Biomaterials and Biomimetics, New York University College of Dentistry, 345 East 24th Street, New York, NY, 10010, USA

    R. Z. LeGeros, S. Lin, R. Rohanizadeh, D. Mijares & J. P. LeGeros

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  1. R. Z. LeGeros
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LeGeros, R.Z., Lin, S., Rohanizadeh, R. et al. Biphasic calcium phosphate bioceramics: preparation, properties and applications. Journal of Materials Science: Materials in Medicine 14, 201–209 (2003). https://doi.org/10.1023/A:1022872421333

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