A Novel Design of Morlet Wavelet to Solve the Dynamics of Nervous Stomach Nonlinear Model

The present study introduces a novel design of Morlet wavelet neural network (MWNN) models to solve a class of a nonlinear nervous stomach system represented with governing ODEs systems via three categories, tension, food and medicine, i.e., TFM model. The comprehensive detail of each category is designated together with the sleep factor, food rate, tension rate, medicine factor and death rate are also provided. The computational structure of MWNNs along with the global search ability of genetic algorithm (GA) and local search competence of active-set algorithms (ASAs), i.e., MWNN-GA-ASAs is applied to solve the TFM model. The optimization of an error function, for nonlinear TFM model and its related boundary conditions, is performed using the hybrid heuristics of GA-ASAs. The performance of the obtained outcomes through MWNN-GA-ASAs for solving the nonlinear TFM model is compared with the results of state of the article numerical computing paradigm via Adams methods to validate the precision of the MWNN-GA-ASAs. Moreover, statistical assessments studies for 50 independent trials with 10 neuron-based networks further authenticate the efficacy, reliability and consistent convergence of the proposed MWNN-GA-ASAs.


Introduction
Solutions of bioinformatics models with deterministic and stochastic numerical technique have paramount importance for the research community due to their exhaustive applications in broad displaces of science and technology. A bioinformatics model for stomach dynamics system with representation of three classes, i.e., tension, food and medicine, i.e., TFM-based ODEs model is taken as a system model for the presented study.

Overview of Nonlinear Stomach Model
In the human body, every organ has its own significance and get disturb with the loss/weakness of any organ. The structure of the human body is linked with one another, e.g., ear is associated with the nose, the nose is connected to the eye, etc. In human structure, the role of the stomach is significant due to the connections of numerous organs in maintaining the health of humans [1]. The stomach's role in the human's body is very crucial and the ancient Greeks observed the intimidating gastric ingredients related with stomach. At the start of sixteenth century, Helmont and Paracelsus [2,3] were aware that stomach comprises acid in the digestion process. The solvent properties of gastric juice of the animal materials accessible by Spallanzani and Reaumur [4,5]. William [6] investigated the emission nature of digestive acid and Beaumont [7] analyzed the patient of a gastric fistula. In the nineteenth century, the innovation of the gastric secretion is organized by the vagotomy ablation and celiac axis as curing interventions. Dale and Laidlaw [8] investigated the histamine using the complex gastric emission, which is focused by the Popielski investigations using the histamine properties of digestive radiation [9]. These stated discoveries helped us to identify the digestive disease using the affected progresses in the pharmacological connotation of peptic ulcer with H2-receptor discoveries of Sir James Black two centuries ago [10]. Edkins [11] presented the gastrin performance and Bayliss and Starling [12] deliberated the secretion. Marshall and Warren [13] conversed the acid based infection in the twentieth century till the innovative discovery of Helicobacter pylori. Jaworski [14] worked on the numerous observations of bacterial populations in intestinal juice.

Mathematical Representation of Nonlinear Stomach Model
The nervous stomach model is represented with three classes, i.e., Tension (T), Food (F) and Medicine (M) that form a nonlinear TFM system as follows [15]: where tension (T), food (F) and medicine (M) are dependent variables or classes, while Ω is the independent variable. In addition, the detail description of the nonlinear TFM system together with the parameter description is provided as follows: • Tension T(Ω) : There are various physical properties of nervous stomach, one of the most significant indication is performance under stressed. The nervous form of the stomach is mainly challenging for the human's structure that does not tolerate to complete the developments due to stress. • Food F(Ω) : Influence of food on stomach disturbance.
The oilier and spicy items of food may play a vital role to disturb the stomach. While food in the form of fruits and vegetable with reasonable oil and spicy ingredient may helpful to reduce the disturbance in the process of the stomach. • Medicine M(Ω) : The medication excess can play an active role to disturb the stomach. The high potency medicines are implemented to progress the minor infections that cause the stomach's abnormality.
The necessary information of the parameters is given in Table 1, while further elaborative details can be seen in [15].

Related Studies and Problem Statement
The variety of artificial intelligence (AI)-based computing paradigm have been introduced by the research community for solving stiff, highly nonlinear and singular models governed with PDEs and ODEs as well as their systems with applications in broad domains of applied science and technology. Thus, the motivation of the present work is to investigate in AI based computational intelligence methodologies to study the dynamics of TFM nonlinear system using the structure of Mayer wavelet neural networks (MWNNs) for Food quality i j , j = 1, 2, 3 Initial conditions the modeling of the system along with the global search ability of genetic algorithm (GA) and local search competence of active-set algorithms (ASAs), i.e., MWNN-GA-ASAs. The recent and relevant studies of such type of stochastic computational paradigm have been exploited to solve numerous nonlinear models, e.g., singular models of higher order represented with Lane-Emden equations [16][17][18], Bouc-Wen hysteresis model for piezostage actuator [19], nonlinear Falkner-Skan systems [20], a fractional form of the singular models [21,22], fluid mechanics problems [23][24][25], nonlinear dynamics of the prey-predator system [26], nonlinear electric circuits [27], nonlinear mosquito release model [28], atomic physics models [29], doubly singular systems [30,31], multi-objective PWR core loading pattern optimization [32], optimal reactive power dispatch [33] and dengue fever system [34]. Keeping in view of these valuable reported studies, the authors are interested to solve the TFM nonlinear model by exploiting MWNN-GA-ASAs based stochastic numerical computing.

The Contribution and Insights
The novel contributions of the design MWNN-GA-ASAs based stochastic scheme are briefly provided as follows: • A nonlinear TFM differential model is successfully presented through the competency of computational paradigm consist of Mayer Wavelet neural networks (MWNNs) modeling and trained with hybrid heuristics of GAs aided with ASAs for rapid refinements. • Stable, reliable and consistent results with good agreement with reference numerical outcomes of the TFM nonlinear system authenticate the worth of the designed computational procedure of MWNN-GA-ASAs. • The authorization of performance is perceived using different statistical assessment procedures to solve the TFM nonlinear system via multiple executions of computational paradigm of MWNN-GA-ASAs. • Beside efficient performance of MWNN-GA-ASAs to solve the TFM nonlinear system, other perks include ease in understanding, smooth implementation, extendibility and wider applicability.

Methodology
The present study is related to solve a TFM-based nonlinear system using the designed computational form of the MWNN-GA-ASAs in two segments, an error-based fitness/ objective function is designed while in second segment, the necessary hybridization steps of GA-ASAs are presented.

Designed Procedure of the Networks
The mathematical representations of the TFM nonlinear system are provided with three classes, i.e., Food, Medicine and Tension, in neural network terminology as follows: while the first derivative representation of (2) is given as follows: Page 4 of 15 The unknown weight vector W is written as follows: An error-based fitness/objective function is constructed using differential equation models of MWNNs by exploiting Morlet wavelet activation kernel f (Ω) = cos (1.75Ω)e −0.5Ω 2 in the hidden layer then the updated networks (2) along with first derivative approximation of the terms in TFM nonlinear system (1) are given as follows [35]: An mean square error function E Fit is presented as follows: (3) M k indicate the proposed approximate solutions representation in MWNN models of the tension class, food class and medicine class, respectively. While, the expressions (5), (6) and (7) represent the objective functions E Fit -1 , E Fit -2 , and E Fit -3 of first, second and third equations of the TFM-based nonlinear system (1), respectively, and expression (8) represents an objective function E Fit -4 linked with the initial conditions of TFM (1). To implement the design MWNNs, one need to optimize E Fit such that E Fit → 0 with the availability of weights of MWNNs trained by appropriate optimization mechanism with on prior requirement of the dataset for training, testing and validation as required in traditionally supervised neural networks.

Optimization: MWNN-GA-ASAs
The necessary overview of the optimization scheme adopted for training of MWNNs based objective function for nonlinear TFM system using the designed integrated computational heuristics GA-ASAs is provided in this section.
GAs are considered to be one the premier global search procedure of optimization implemented to solve many renewed problems of the linear/nonlinear systems. GA can be implemented to solve both optimization systems with constrained and unconstrained forms is different domain since their introduction in early seventies of last century. GAs are typically exploited the global search to find the candidate solutions by modifying population at each generation through reproduction operators of crossover, mutations and selection. In recent years, GA is particularly implemented in optimization problems in the hospitalization outflow models [36], brain tumor images [37], optimization of layer thickness in multilayer piezoelectric Table 2 Optimization procedures via MWNN-GA-ASAs for the TFM nonlinear system transducer [38], economic load dispatch problems [39], nonlinear Falkner-Skan systems [40], prediction differential system [41], optimization steps of cloud service [42], periodic model [43], monorail vehicle dynamics [44] and nonlinear electric circuit models [45]. The performance or optimization strength of GAs is further enhanced with the combination of local search procedure.
Active set algorithms (ASA) are a local search optimization mechanics generally applied to solve both form of the constrained/unconstrained optimization tasks/models. ASAs are well-organized optimization methods used to compute the results competently. In recent few decades, ASAs are implemented for OPF problem in DC grids [46], optimum stockpile and period length [47], continuum structures subjected to harmonic force excitation [48], dynamic positioning of marine [49] and transient heat conduction problem [50].
Therefore, it is presented study, the process of training of weights of MWNNs is accomplished with the knacks of hybrid heuristics of GA-ASAs. The pseudocode of GA-ASAs is provided in the Table 2 with necessary parameter settings and details of procedural steps for both GAs and ASAs.

Performance Processes
The statistical performances using the mean absolute deviation (MAD), Theil's inequality coefficient (TIC), variance account for (VAF) and semi interquartile range (S.I.R) along their global illustrations are implemented to solve the TFM nonlinear system and their definitions are shown mathematically as follows:

Simulation of the Results
The TFM nonlinear system given in Eq. (1) is numerically studied using the designed integrated heuristics of MWNN-GA-ASAs and its performance is presented in this section. The results obtained form MWNN-GA-ASAs for the TFM nonlinear system are compared with the Adams numerical solutions, which are calculated as per procedure and setting reported in [51,52]. The results of MWNN-GA-ASAs are also described through convergence analysis, AE and performance indices elaborately in this section to access the accurate performance.
The simplified mathematical form of the TFM nonlinear system (1) using appropriate parameters is given as [15]: An error function based on TFM nonlinear system (13) becomes as follows: The design MWNN models of differential equation for the TFM nonlinear system representing the dynamics of nervous stomach based on 30 variables or 10 neurons is solved by computational procedure of integrated heuristics of GA-ASAs are per details and procedure steps given in the last section. The mathematical expression based outcomes of best performing weight vectors are given below to solve the TFM nonlinear system as: The numerical values representation of best weights and approximate solutions to solve the TFM nonlinear model using the MWNN-GA-ASAs are illustrated in Fig. 1. The best weights for the TFM nonlinear system have been provided in Fig. 1a-c using 10 numbers of neurons in MYNNs. The values of these weight vector are used to obtain the above Eqs. (15)(16)(17). The result comparisons for each class of the TFM nonlinear system is provided in Fig. 1d-f. The comparative assessment of the mean and best results accomplished through the MWNN-GA-ASAs is performed with the Adams numerical solutions to solve the TFM nonlinear system. The accurate MWNN-GA-ASAs performance is witnessed through the overlapping of the solutions.
The close to optimal values of all these global measures G-TIC, G-MAD) and G-EVAF indicate the correctness, precision and efficacy of the integrated computational heuristics of MWNN-GA-ASAs.

Conclusions
A novel design of the Morlet wavelet neural network is presented to solve the TFM nonlinear system together with the capability of local search ASAs and global search GAs based optimization schemes, i.e., MWNN-GA-ASAs. An error function is presented based on the TFM nonlinear (e) (f) (g) differential system, its boundary conditions and then optimization is performed using the capabilities of integrated heuristics of GA-ASAs. The obtained numerical outcomes via MWNN-GA-ASAs are compared with the Adams numerical results that evidently show the precision of the TFM nonlinear differential system with values of the AE lie around 10 -06 to 10 -08 . Moreover, the magnitudes of MAD, TIC and EVAF operators verify the performance for solving the TFM nonlinear differential system. The assessments through statistical indicators for multiple independent executions using proposed MWNN-GA-ASAs based on the MED, Min, S.I.R, Mean, SD and Max operatives authenticate its correctness and worth. Furthermore, close to optimal values of global measures including G-TIC, G-MAD and G-EVAF indicate the correctness, precision and efficacy of the integrated computational heuristics of MWNN-GA-ASAs for solving the TFM nonlinear differential system. In future, the designed form of the computational MWNN-GA-ASAs is capable to solve the nonlinear systems' biological studies [53][54][55], financial mathematical models [56,57] and fluid dynamic models [58][59][60].

Conflict of interest
The authors state that they are not in any conflict of interest.
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