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Intrathecal pramipexole and selegiline for sensory and motor block in rats

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Abstract

Background

The purpose of the study was to investigate spinal sensory and motor block by antiparkinsonian drugs (pramipexole and selegiline), and the combination of pramipexole and the local anesthetic lidocaine.

Methods

Using a technique of spinal blockade in rats, the effects of pramipexole, selegiline, and coadministration of pramipexole and lidocaine on spinal blockades of motor and sensory function were investigated.

Results

Under a concentration of 100 mM, pramipexole displayed more potent and had a longer duration of nociceptive, proprioceptive, and motor block than selegiline, whereas pramipexole and selegiline were less potent in comparison to lidocaine. Pramipexole produced spinal nociceptive, proprioceptive, and motor blocks in a dose-related manner. On the ED50 (50% effective dose) basis, the rank-order potency on nociceptive, proprioceptive, and motor block was pramipexole < lidocaine. The spinal block duration of pramipexole was greater than lidocaine at every equipotent dose tested (ED25, ED50, and ED75). Coadministration of lidocaine (ED50 or ED95) with pramipexole (4.5 μmol/kg) improved the effect (efficacy) and duration of the spinal block.

Conclusions

Pramipexole and selegiline were less potent than lidocaine to block sensory and motor responses. The duration of the spinal anesthetic effect of pramipexole was longer than lidocaine. At a non-effective dose, pramipexole increased the duration of efficacy of lidocaine.

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Abbreviations

ANOVA:

Analysis of variance

AUC:

Area under the curve

COMT:

Catechol-O-methyltransferase

ED25s:

25% Effective doses

ED50 :

50% Effective dose

FDA:

U.S. Food and Drug Administration

IASP:

International Association for the Study of Pain

MAO-B:

Monoamine oxidase B

% MPE:

Percent of the maximal possible effect

Nav channels:

Voltage-gated sodium channels

OUD:

Opioid use disorder

% PE:

Percent of the possible effect

SAS NLIN Procedures:

Statistical analysis system nonlinear procedures

Tukey’s HSD test:

Tukey’s honestly significant difference test

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Acknowledgements

The authors gratefully acknowledge the financial support provided by the grant (MOST 110-2314-B-039-014-MY3; MOST 109-2918-I-039-001) from the Ministry of Science and Technology (Taiwan) and by the grant (CMU110-MF-110) from the China Medical University (Taiwan).

Author information

Author notes

  1. An-Kuo Chou and Ching-Hsia Hung have contributed equally to this work.

  2. Chun-Chang Yeh and Yu-Wen Chen have contributed equally to this work.

Authors and Affiliations

  1. Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan

    Chun-Chang Yeh & Jhi-Joung Wang

  2. School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan

    Chong-Chi Chiu

  3. Department of General Surgery, E-Da Cancer Hospital, Kaohsiung, Taiwan

    Chong-Chi Chiu

  4. Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan

    Jhi-Joung Wang & Yu-Wen Chen

  5. Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan

    An-Kuo Chou

  6. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

    An-Kuo Chou

  7. Department of Physical Therapy, College of Health Care, China Medical University, Taichung, Taiwan

    Yu-Wen Chen

  8. Department of Physical Therapy, College of Medicine, National Cheng Kung University, No.1 Ta-Hsueh Road, Tainan, Taiwan

    Guan-Cheng Zhu & Ching-Hsia Hung

  9. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Ching-Hsia Hung

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  1. Chun-Chang Yeh
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Yeh, CC., Chiu, CC., Wang, JJ. et al. Intrathecal pramipexole and selegiline for sensory and motor block in rats. Pharmacol. Rep 74, 470–480 (2022). https://doi.org/10.1007/s43440-022-00368-x

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  • DOI: https://doi.org/10.1007/s43440-022-00368-x

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