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Bioprocessing 4.0 in biomanufacturing: paving the way for sustainable bioeconomy

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Abstract

The past decade has been envisaged as a period of unprecedented growth and development in the bioprocessing industry due to the increasing prominence of manufacturing bioproducts encompassing day-to-day life. Bioprocesses are the heart of biotechnology and represent the most dynamic constituent for conceptualizing the bioeconomy as it has the potential to tackle the most burgeoning problems such as climatic adversity, global population growth, reduced ecosystem resilience. The promising amalgamation of digitalization, biologicalization, and biomanufacturing paved the way for an emerging concept of “bio-intelligent value addition” or more prominently Bioprocessing 4.0 that enables the transformation in the landscape of biomanufacturing. Despite its positive credentials, the technology is facing technical, organizational, economical, and likely some unforeseen challenges that must be resolved for its successful implementation for hailing the sustainability development goals (SDGs) of bioeconomy. Though the road of bioeconomy is quite arduous, the continuous demand for bioproducts and their timely delivery at a faster rate necessitates the culture of sharing knowledge, digitalization, automation, and development of flexible modular and podular facility footprints to accelerate biomanufacturing. Therefore, it is worth summarizing the major portfolios of Bioprocessing 4.0 such as conception of biofoundry, bioprocess intensification strategies, process and data analytics, software and automation, and its synergistic correlation with bioeconomy. Thus, the present article advocates about the technological glance of Bioprocessing 4.0 along with technical challenges and future research priorities for sparking the glory of this industrial landscape for enshrining the bioeconomy.

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Acknowledgements

The authors greatly acknowledge the support of Gautam Buddha University, (Greater Noida), Saveetha Institute of Medical and Technical Sciences, (Chennai) and Patanjali Research Institute (Haridwar) for writing this manuscript.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. School of Biotechnology, Gautam Buddha University, Greater Noida, U.P., India

    Kamini Pandey, Muskan Pandey & Barkha Singhal

  2. Ecotoxicity and Bioconversion Laboratory, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, 602105, India

    Vinay Kumar

  3. Patanjali Research Institute, Haridwar, Uttrakhand, India

    Upasana Aggarwal

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  1. Kamini Pandey
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Contributions

BS conceptualized the idea and wrote the manuscript and VK has critically revised the manuscript by giving his meticulous suggestions. KP has formulated three figures and helps in technical assistance related to referencing of manuscript and MP has made rest of diagrams including graphical abstract. UA has revised the current progress section of the manuscript.

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Correspondence to Barkha Singhal.

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Pandey, K., Pandey, M., Kumar, V. et al. Bioprocessing 4.0 in biomanufacturing: paving the way for sustainable bioeconomy. Syst Microbiol and Biomanuf 4, 407–424 (2024). https://doi.org/10.1007/s43393-023-00206-y

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