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Understanding the Mechanisms of Diminished Ovarian Reserve: Insights from Genetic Variants and Regulatory Factors

  • Reproductive Genetics: Review
  • Published:
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Abstract

Delaying childbearing age has become a trend in modern times, but it has also led to a common challenge in clinical reproductive medicine—diminished ovarian reserve (DOR). Since the mechanism behind DOR is unknown and its clinical features are complex, physicians find it difficult to provide targeted treatment. Many factors affect ovarian reserve function, and existing studies have shown that genetic variants, upstream regulatory genes, and changes in protein expression levels are present in populations with reduced ovarian reserve function. However, existing therapeutic regimens often do not target the genetic profile for more individualized treatment. In this paper, we review the types of genetic variants, mutations, altered expression levels of microRNAs, and other related factors and their effects on the regulation of follicular development, as well as altered DNA methylation. We hope this review will have significant implications for the future treatment of individuals with reduced ovarian reserve.

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This research was supported by the National Natural Science Foundation of China (No.81960278 and No.82360303), the Intra-Hospital Funds of the First Hospital of Lanzhou University (ldyyyn2022-72), and the Excellence Program Project for students of the First Clinical Medical School of Lanzhou University (20230060173).

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  1. The First Clinical Medical College of, Lanzhou University, Lanzhou, China

    Qinying Zhu & Hao Ma

  2. Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou, China

    Jing Wang

  3. Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Gynecological Oncology, No.1, Donggangxi Rd, Chengguan District, Lanzhou, 730000, China

    Xiaolei Liang

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  1. Qinying Zhu
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  2. Hao Ma
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  3. Jing Wang
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  4. Xiaolei Liang
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Correspondence to Xiaolei Liang.

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Zhu, Q., Ma, H., Wang, J. et al. Understanding the Mechanisms of Diminished Ovarian Reserve: Insights from Genetic Variants and Regulatory Factors. Reprod. Sci. 31, 1521–1532 (2024). https://doi.org/10.1007/s43032-024-01467-1

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  • DOI: https://doi.org/10.1007/s43032-024-01467-1

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