Abstract
Cervical endometriosis is an uncommon form of endometriosis that is frequently diagnosed incidentally during histopathological evaluation of a hysterectomy or cervical biopsy specimens. Although some cases may be asymptomatic, the symptoms in some patients range from life-threatening hemorrhage to severe chronic pelvic pain. In asymptomatic patients, no further intervention might be required apart from observation and follow-up; however, patients with significant symptoms will require surgery. Primary cervical endometriosis is defined as presence of endometrial tissue on the anterior lip of the cervix, limited to the cervix surface and not extending below the squamous epithelium. Secondary cervical endometriosis is more common than the primary type and describes the disease extensions from the pelvis, or usually the rectovaginal septum. Superficial endometriosis is usually diagnosed by fine-needle aspiration, colposcopy, and cervical biopsy after a routine cervical smear, as endometrial cells detected during a PAP smear may be mistakenly removed as atypical glandular cells. Deep endometriosis may cause pelvic pain, vaginal bleeding, and spotting. In this case report, we present a rare case of cervical endometriosis, characterized by pelvic pain and menstrual irregularity, with endometrioma and adenomyosis, confirmed by histopathological evaluation of the specimen. A summary of the cervical endometriosis cases overview has been made to describe the changing clinical landscape of this rare condition.
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04 May 2023
A Correction to this paper has been published: https://doi.org/10.1007/s43032-023-01254-4
References
Ata B, Ates U, Usta T, Attar E. Cervical endometriosis, a case presenting with ıntractable spotting. MedGenMed. 2005;7:64.
Veiga-Ferreira MM, Leiman G, Dunbar F, Margolius KA. Cervical endometriosis: facilitated diagnosis by fine needle aspiration cytologic testing. Am J Obstet Gynecol. 1987;157:849–56. https://doi.org/10.1016/S0002-9378(87)80070-4.
Ismail SM. Cone biopsy causes cervical endometriosis and tubo-endometrioid metaplasia. Histopathology. 1991;18:107–14. https://doi.org/10.1111/J.1365-2559.1991.TB01452.X.
Siddal RS, Mack HC. Primary endometriosis of the vaginal portion of the cervix uteri. Am J Obstet Gynecol. 1949;58:765–9. https://doi.org/10.1016/S0002-9378(16)39234-1.
Swetha P, Nagashree U, Kondammal R. A rare presentation of deep infiltrating cervical endometriosis mimicking cervical cancer. Int J Reprod Contracept Obstet Gynecol. 2020;9:3903–5. https://doi.org/10.18203/2320-1770.IJRCOG20203881.
Félix A, Nogales FF, Arias-Stella J. Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens. Int J Gynecol Pathol. 2010;29:185–8. https://doi.org/10.1097/PGP.0B013E3181B7015E.
Lundeen SJ, Horwitz CA, Larson CJ, Stanley MW. Abnormal cervicovaginal smears due to endometriosis: a continuing problem. Diagn Cytopathol. 2002;26:35–40. https://doi.org/10.1002/DC.10038.
Selo-Ojeme D, Freeman-Wang T, Khan NH. Post-coital bleeding: a rare and unusual presentation of cervical endometriosis. Arch Gynecol Obstet. 2006;273:370–3. https://doi.org/10.1007/S00404-005-0034-X.
Mendoza GO, Castañón FJM, Hernández M, Maguregui SCO, Orozco VMM. [Deep cervical endometriosis causing profuse vaginal bleeding. Case report and literature review]. Ginecol Obstet Mex 2009;77(11)518–22. https://pubmed.ncbi.nlm.nih.gov/20085136/. Accessed 19 Oct 2022
Shaw RW. An Atlas of Endometriosis First edition. Parthenon Publishing, Carnforth, UK. 1993. https://www.abebooks.com/first-edition/Atlas-Endometriosis-Shaw-R-W-Parthenon/1317788171/bd#&gid=1&pid=1. Accessed 9 Oct 2022
Matoba Y, Tsuji K, Morisada T, Takahashi M, Kobayashi Y, Nakamura M, Banno K, Aoki D. Massive hemorrhage due to cervical endometriotic cyst rupture: two case reports and a literature review. Am J Case Rep. 2021;22:e934120. https://doi.org/10.12659/AJCR.934120
Wong FWS, Lim CED, Karia S, Santos L. Cervical endometriosis: case series and review of literature. J Obstet Gynaecol Res. 2010;36:916–9. https://doi.org/10.1111/J.1447-0756.2010.01209.X.
Li J, Liu R, Tang S, Feng F, Liu C, Wang L, Zhao W, Zhang T, Yao Y, Wang X, Sun C. Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis. Arch Gynecol Obstet. 2018;299:35–46. https://doi.org/10.1007/S00404-018-4968-1.
Matalliotakis M, Matalliotaki C, Zervou MI, Krithinakis K, Kalogiannidis I, Goulielmos GN. Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases. Women Health. 2021;61:896–901. https://doi.org/10.1080/03630242.2021.1991073.
Baker PM, Clement PB, Bell DA, Young RH. Superficial endometriosis of the uterine cervix: a report of 20 cases of a process that may be confused with endocervical glandular dysplasia or adenocarcinoma in situ . Int J Gynecol Pathol. 1999;18(3):198–205. https://pubmed.ncbi.nlm.nih.gov/12090586/. Accessed 9 Oct 2022
Bozdag G, Igci N, Calis P, Ayhan B, OzelDemiralp D, Mumusoglu S, Yarali H. Examination of cervical swabs of patients with endometriosis using Fourier transform infrared spectroscopy. Arch Gynecol Obstet. 2019;299:1501–8. https://doi.org/10.1007/S00404-019-05105-Z.
Wang S, Li XC, Lang JH. Cervical endometriosis: clinical character and management experience in a 27-year span. Am J Obstet Gynecol. 2011;205:452.e1-452.e5. https://doi.org/10.1016/J.AJOG.2011.06.070.
Hashimi SA, Bhatia Y, Singh S. Polypoid endometriosis of cervix: a case report. Gynecol Obstet Reprod Med. 2023;29(1):72-4. https://doi.org/10.21613/GORM.2021.1197.
Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS. Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report. J Korean Med Sci. 2009;24:767–71. https://doi.org/10.3346/JKMS.2009.24.4.767.
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Atalay Mert, S., Dilbaz, B., Ercan, E.E. et al. A Rare Case of the Cervical Endometriosis and Overview of the Literature. Reprod. Sci. 30, 2882–2886 (2023). https://doi.org/10.1007/s43032-023-01238-4
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DOI: https://doi.org/10.1007/s43032-023-01238-4