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Is It Possible to Treat Infertility with Stem Cells?

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Abstract

Infertility is a major health problem, and despite improved treatments over the years, there are still some conditions that cannot be treated successfully using a conventional approach. Therefore, new options are being considered and one of them is cell therapy using stem cells. Stem cell treatments for infertility can be divided into two major groups, the first one being direct transplantation of stem cells or their paracrine factors into reproductive organs and the second one being in vitro differentiation into germ cells or gametes. In animal models, all of these approaches were able to improve the reproductive potential of tested animals, although in humans there is still too little evidence to suggest successful use. The reasons for lack of evidence are unavailability of proper material, the complexity of explored biological processes, and ethical considerations. Despite all of the above-mentioned hurdles, researchers were able to show that in women, it seems to be possible to improve some conditions, but in men, no similar clinically important improvement was achieved. To conclude, the data presented in this review suggest that the treatment of infertility with stem cells seems plausible, because some types of treatments have already been tested in humans, achieving live births, while others show great potential only in animal studies, for now.

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  1. Department of Human Reproduction, Division of Gynaecology, University Medical Centre Ljubljana, Slajmerjeva 3, Ljubljana, Slovenia

    P. Petric, E. Vrtacnik-Bokal & M. Stimpfel

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Petric, P., Vrtacnik-Bokal, E. & Stimpfel, M. Is It Possible to Treat Infertility with Stem Cells?. Reprod. Sci. 28, 1733–1745 (2021). https://doi.org/10.1007/s43032-021-00566-7

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