Abstract
A recent study in Nature Structural and Molecular Biology reveals that chromatin-associated PDHE1α generates acetyl-CoA near DNA double-strand breaks, crucial for chromatin remodeling and DNA repair. PDHE1α recruitment depends on PARP1 and impacts genome stability and cancer therapy resistance. This research sheds light on DNA damage response and chromatin acetylation regulation.
This is a preview of subscription content, log in via an institution to check access.
References
Murr, R., et al. (2006). Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nature Cell Biology, 8, 91–99. https://doi.org/10.1038/ncb1343
Shogren-Knaak, M., et al. (2006). Histone H4–K16 acetylation controls chromatin structure and protein interactions. Science, 311, 844–847. https://doi.org/10.1126/science.1124000
Sivanand, S., et al. (2017). Nuclear acetyl-CoA production by ACLY promotes homologous recombination. Molecular Cell, 67, 252-265.e256. https://doi.org/10.1016/j.molcel.2017.06.008
Xu, Y., et al. (2012). Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair. Molecular Cell, 48, 723–733. https://doi.org/10.1016/j.molcel.2012.09.026
Yi, C. H., et al. (2011). Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell, 146, 607–620. https://doi.org/10.1016/j.cell.2011.06.050
Zhang, J., et al. (2023). PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair. Nature Structural & Molecular Biology. https://doi.org/10.1038/s41594-023-01107-3
Author information
Authors and Affiliations
Contributions
JY designed the study. BH wrote the manuscript. YC reviewed and edited the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflicts of interest in relation to this work.
Rights and permissions
About this article
Cite this article
Huang, B., Chen, Y. & Yuan, J. PDHE1α in DNA damage repair: a critical chromatin acetylation regulator. GENOME INSTAB. DIS. 4, 349–350 (2023). https://doi.org/10.1007/s42764-023-00112-6
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s42764-023-00112-6