Abstract
Recently, the plants-derived bioactive components received a greater interests due to their significant anti-carcinogenic properties. Euphorbia hirta is a well known herbal plant, which is highlighted to show a remarkable anticancer activities against several types of cancers. In this study, we analyzed the in vitro antitumor action of E. hirta against the liver cancer HepG2 cell line. Our current findings demonstrated the existence of several bioactive metabolites in the E. hirta plant, which is studied through phyotochemical analysis and characterized through chromatogram and FT-IR analysis. The administration of E. hirta plant extract exhibited the remarkable diminution in the cell proliferation and effectively induced the apoptosis in the HepG2 cells. The outcomes of fluorescence analysis revealed that the E. hirta plant extract decreased the MMP level, and increased the accumulation of ROS and apoptosis in the liver cancer HepG2 cells. In overall, the findings of the invitro studies showed that E. hirta plant extract effectively inhibited the cell proliferation and triggered the apoptosis in the liver cancer HepG2 cells. Hence, it can be a promising source to discover the possible antitumor drugs from this plant extract to treat the liver cancer.
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The authors would like to thank Shri Sakthikailassh Women’s College for their kind support for all lab studies.
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Kalaivani, S., Jayanthi, S., Revathi, K. et al. Phytochemical profile of Euphorbia hirta plant extract and its in vitro anticancer activity against the liver cancer HepG2 cells. Vegetos 37, 528–535 (2024). https://doi.org/10.1007/s42535-023-00621-5
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DOI: https://doi.org/10.1007/s42535-023-00621-5