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Treatment Outcomes and Prognostic Factors in Patients with Low-Grade Glioma

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Abstract

Low-grade gliomas are responsible for approximately 15% of all adult primary intracranial tumors. The treatment strategy is still controversial. In this study, we aimed to evaluate the treatment outcomes and predictive factors for local control and overall survival in this population. We have reviewed 50 cases of adult patients with low-grade gliomas diagnosed from 2009 to 2019. All patients underwent surgical intervention followed by post-operative radiotherapy, and some also received chemotherapy. With a median follow-up of 21 months for surviving patients, the 2-year overall and progression-free survival rates were 83 and 82%, respectively. Only the different radiotherapy methods showed independent prognostic values for overall survival and disease-free survival of our patients. In this study, we found that only type of radiotherapy (2D vs. 3D) has prognostic value for 2-year PFS and overall survival rates. There need to be further efforts to optimize radiotherapy techniques and to integrate new therapeutic modalities.

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Acknowledgements

We thank the patients and their families who generously agreed to participate in this study and we thank the hospital, doctors, nurses, and personnel who helped in the process.

Funding

This study was funded and supported by Tehran University of Medical Sciences (TUMS), Grant no: 97-03-207-40441.

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Authors and Affiliations

  1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mahsa Mohammadpour

  2. Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Reza Ghalehtaki, Ebrahim Esmati & Ali Kazemian

  3. Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran

    Soheil Naderi

  4. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mostafa Farzin

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  1. Mahsa Mohammadpour
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Contributions

RG and EE and AK conceived and designed the analysis, MM and SN collected the data and wrote the paper, and MF and SN contributed data or analysis tools.

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Correspondence to Reza Ghalehtaki.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Medical University of A (No. IR.TUMS.VCR.REC.1398.033).

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Mohammadpour, M., Ghalehtaki, R., Naderi, S. et al. Treatment Outcomes and Prognostic Factors in Patients with Low-Grade Glioma. SN Compr. Clin. Med. 3, 1891–1897 (2021). https://doi.org/10.1007/s42399-021-00914-3

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