Principles of Disinfectant Use and Safety Operation in Medical Facilities During Coronavirus Disease 2019 (COVID-19) Outbreak

Medical collapse became a major concern under coronavirus disease 2019 (COVID-19) outbreak; prevention of medical accidents is essential during disinfection either. The objective of this review is to enhance the awareness regarding the safety aspects towards infection prevention practices and to offer solutions for safe patient care practices including side effects of disinfectants and precaution in specific medical facilities especially in hemodialysis rooms, intensive care unit, hyperbaric oxygen therapy (HBO) chambers, or patient transport vehicle. Literature was researched that was obtained from studies of human coronavirus infections, including the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS), and created a summary of the characteristics of these disinfectants. This review is not intended to replace infection prevention policies and procedures established by hospitals, and manufacturers, but to provide some update confidence in the safety measures that each medical facility already uses and to offer additional input that should optimally reduce the risk of infection.


Introduction
The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As human coronaviruses can remain infectious on inanimate surfaces for several days [1], surface disinfection with chemicals is inevitable. Coronavirus is an RNA enveloped virus [2] and generally not highly resistant to disinfectants and can also be inactivated by heat and ultraviolet (UV) irradiation [3]. However, inadequate use of disinfectants causes side effects to the medical staff, and inadequate use in poor ventilation may result in fire, gas poisoning, explosion, or equipment corrosion. Disinfection in a non-critical or semicritical area that does not have negative pressure rooms deserves attention. As illustrated in Fig. 1, a special attention must be paid to situations where the risk factors overlap. Flammable disinfectants under oxygen use may cause an explosion triggered by static electricity or excessive heat; also, poisoning may occur with gas producible disinfectants under poor ventilation. Thus, this review focuses on the infection prevention practices and safety aspects including equipment protection measures against potential damage. The aim of this review is to update the confidence for all the caregivers who already complying with health and safety recommendations and following strict training. The efficacy data was obtained from studies of two types of human coronavirus infections, the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS), and created a summary of the characteristics of these disinfectants. their benefits outweigh the infection risk, for example, when a treatment is lifesaving or is required as part of intensive care such as patient transport vehicle [5].

Alert for Contamination Prevention
Transmission-based precautions is necessary for this condition [4]. 3. Avoid encounter of outpatients and inpatients at the same place. If multiple patients need to be treated at the same space at the same time, limit the number of patients and keep the patients as far as possible from each other (ideally 1 m or more) unless partition was prepared. 4. There is ability for SARS-CoV-2 to remain in the context of remarkably high bioburdens such as body fluid, vomit, and stool. Wear gloves when processing [4].

5.
There is a report that 30% of medical staff was infected in a hospital; a safety measure for medical staff is also important [6].
Alert for Procedures

Alert for Disinfection
When disinfecting a SARS-CoV-2-contaminated space or surface, exposure time and concentration of disinfectants are important. Follow the recommended disinfectants and concentration as indicated by the CDC and ensure the environmental disinfection procedure based on your local decontamination guidelines. In addition, please do not forget the caregiver's safety as well [4]. Many disinfectants cause side effects such as eye irritation, mucous irritation, and contact dermatitis. Thus, environmental disinfection needs to be performed with adequate personal protective equipment (PPE) and training. Also, some disinfectants have a chance of explosion and gas poisoning with their flammability and toxicity. Even if the chance is rare, the accident level is high. Thus, check for a room-or area-specific conditions associated with the use of the disinfectant, such as flammability (especially under oxygen use), and check for a risk of toxic gas production during the disinfecting process. Do not be sprayed in closed spaces. Confirm with the vendor that the disinfectant is safe to use on the specific equipment materials and will not cause corrosion or breakdown. To understand the advantages and disadvantages of each disinfectant, please refer to our quick guide for disinfectant use (Table 1).

Flammable Agents
1. Ethanol (70-95%) or isopropanol (50-100%) inactivates SARS-CoV-2 [8]; however, it must be used with adequate ventilation. Wipe with an impregnated sheet followed by forced ventilation and allow drying time at least 30 min. These substances are volatile and flammable and can cause an explosion when used in closed spaces that contains higher oxygen concentration. Ethanol or isopropanol may cause acrylic resin degradation when disinfecting synthetic resin materials. 2. Hydrogen peroxide, 0.5%, inactivates some coronaviruses, including SARS-CoV-2 [1]; however, it is explosive with heat. 3. 0.5% of phenolic cresol must be used with adequate ventilation. This compound is flammable and is toxic by inhalation. Rubber, aluminum compounds, zinc, lead, plated iron, and polyethylene can be corroded by this compound [9].
Gas Produce or Toxic Agents 1. Avoid using glutaraldehyde in closed spaces. It may cause mucous membrane irritation in the eyes and in the respiratory system, as well as skin side effects [10]. Use glutaraldehyde only in ventilated areas, according to each medical institution's guidance. 2. Avoid using formaldehyde in closed spaces. It may cause mucous membrane irritation in the eyes and in the respiratory system, as well as skin side effects.
Corrosion or Breakdown 1. Avoid using sodium hypochlorite (effective concentration, 0.21%) on metals, on acrylic resins either, because it is highly alkaline and has a strong corroding effect [11]. 2. Avoid using potassium peroxymonosulfate with spray, because it is toxic by inhalation. Aluminum compounds, zinc, and plated iron can be corroded by this compound. 3. The disinfecting effect of chlorhexidine gluconate on RNA viruses has not been proven [1]. Also, the metal corroding effect was reported [11].

Recommended Disinfectants for Equipment in Closed Spaces
1. 200-280 nm (UV-C) light can quickly disinfect the air [12], inactivating SARS-CoV-2 [8]; however, the shadow of the irradiation is not disinfected. Avoid direct irradiation to organic glassware such as polyvinyl chloride. It is possible that UV-C is safe for skin genotoxicity [13]; however, its effect to the naked eye that may cause impaired vision is not confirmed [14]. Also, UV light does not penetrate plastic and glass [8].
Disinfectants that Are Not Suitable Against SARS-CoV-2 1. The disinfecting effect of quaternary ammonium salts (benzalkonium chloride, benzethonium chloride) on RNA viruses such as coronaviruses is weak [1]. 2. The disinfecting effect of alkyl diaminoethyl glycine hydrochloride on RNA viruses has not been proven.

Other disinfectants approved by the United States
Environmental Protection Agency (EPA) are listed on the agency's website [15] Conclusions An accurate understanding of the advantages and disadvantages of disinfectants and operation may provide updated Hydrogen peroxide A filled circle indicates effective or recommend. An X indicates ineffective or not recommended. UV, ultraviolet; M, practicable for metal but not for glassware; F, flammable; G, toxic gas-producing; W, weak 1 When mixed with ammonia confidence in safety measures and may reduce the risk of infection.