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A multi-step continuous flow synthesis of pomalidomide

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Abstract

The immunomodulatory drugs (IMiDs) thalidomide, pomalidomide, and lenalidomide are widely used to treat multiple myeloma. The permanent need of IMiDs analogues in clinical screening and practice has created the demand to find a reliable and robust method for their preparation. To reach this goal, the use of flow chemistry is quite appealing, allowing a safe operation, an excellent reproducibility and an efficient process. Herein, we describe a continuous 3–4 step flow approach for the synthesis of the pomalidomide (38–47% overall yield) and a few analogues.

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Acknowledgements

This work is part of the API program supported by the European Union through the operational program FEDER/FSE 2014–2020 (no. 20E04976) and FNADT-DRACCARE program 2020–2023 ((N)15179). This work has been partially supported by University of Rouen Normandy, INSA Rouen Normandy, the Centre National de la Recherche Scientifique (CNRS), European Development Fund (ERDF), Labex SynOrg (ANR-11-LABX-0029), Carnot Institute I2C, the graduate school for research XL-Chem (ANR-18-EURE-0020 XL CHEM), and by Région Normandie. T.P. thanks the Institut Universitaire de France (IUF) for support.

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Authors and Affiliations

  1. Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France

    Maria Ivanova, Julien Legros, Thomas Poisson & Philippe Jubault

  2. Institut Universitaire de France, Paris, France

    Thomas Poisson

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  1. Maria Ivanova
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  2. Julien Legros
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  3. Thomas Poisson
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  4. Philippe Jubault
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Correspondence to Julien Legros, Thomas Poisson or Philippe Jubault.

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Ivanova, M., Legros, J., Poisson, T. et al. A multi-step continuous flow synthesis of pomalidomide. J Flow Chem 12, 383–387 (2022). https://doi.org/10.1007/s41981-022-00223-3

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