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Continuous synthesis of benzaldehyde by ozonolysis of styrene in a micro-packed bed reactor

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Abstract

Due to the inherent safety and high mass/heat transfer efficiency of microreactor, the continuous micro-reaction technology has been widely applied in hazardous chemistry recently. In this work, a continuous ozonolysis system based on micro-packed bed reactors (µPBRs) was developed with the synthesis of benzaldehyde as a model reaction. The effects of operating variables (e.g., stirring time, molar ozone/olefin ratio, reaction pressure, reaction temperature and liquid residence time) on the olefins conversion and product distribution were investigated. Based on the experimental results, the optimum reaction conditions are as follows: stirring time 1 h, molar ratio of ozone to olefin 1.2, reaction pressure 0.1 MPa, and the reaction temperature ranging from − 15 to 10℃, as opposed to the low temperature (<-50℃) routinely employed for batch operation. In addition, the full conversion of styrene and a benzaldehyde yield of ~ 93% was observed with the liquid residence time of 3.8–30.8 s. Consequently, the flow ozonolysis technique upon µPBRs allows for a sustainable, safe and efficient approach to oxidize olefins to aldehydes/ketones compared to traditional methods.

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Acknowledgements

We gratefully acknowledge the supports of National Natural Science Foundation of China (21978146, 22022809) and National Key Research and Development Program of China (2019YFA0905100) on this work.

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Authors and Affiliations

  1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, China

    Fengyan Lou, Qiang Cao, Chenghao Zhang & Jisong Zhang

  2. College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, Zhejiang, China

    Fengyan Lou & Qining Wang

  3. College of Biological, Chemical Science and Engineering, Jiaxing University, 314001, Jiaxing, Zhejiang, China

    Fengyan Lou & Ning Ai

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  1. Fengyan Lou
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  2. Qiang Cao
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  3. Chenghao Zhang
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Lou, F., Cao, Q., Zhang, C. et al. Continuous synthesis of benzaldehyde by ozonolysis of styrene in a micro-packed bed reactor. J Flow Chem 12, 307–315 (2022). https://doi.org/10.1007/s41981-022-00220-6

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