Abstract
Purpose
Ovarian cancer is the seventh most frequent cancer diagnosis worldwide and is responsible for more deaths than any other gynaecologic malignancy. Changes in global DNA methylation have been suggested to cause genomic instability and risk of cancer. Global DNA hypomethylation is often found to be reduced in cancer and is a hallmark of human cancers. The present study aimed to evaluate global DNA methylation percentage (%5-mC) in women with ovarian cancer.
Methods
DNA was extracted from peripheral blood leucocytes of the ovarian cancer patients and controls. Global methylation pattern was evaluated using the Methylated DNA Quantification Kit.
Results
The methylation status revealed a lower mean %5-mC in cases (42.42) as compared to that of controls (58.66).
Conclusion
Global methylation levels were lower in ovarian cancer cases as compared to the controls. Though the sample size of the present study is relatively small, the study provides evidence linking ovarian cancer risk with global DNA hypomethylation.
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Samtani, R., Sharma, N. Global DNA Methylation Profile in Ovarian Cancer Patients. Indian J Gynecol Oncolog 21, 83 (2023). https://doi.org/10.1007/s40944-023-00757-x
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DOI: https://doi.org/10.1007/s40944-023-00757-x