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Self-assembled quercetin-Fe3+ nanoparticles for synergetic near-infrared light-triggered low-temperature photothermal/glutathione-activated chemodynamic therapy

自组装槲皮素-Fe3+纳米颗粒用于协同近红外光触发 的低温光热/谷胱甘肽激活化学动力学治疗

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Abstract

Combining photothermal therapy (PTT) with chemodynamic therapy (CDT) is an efficacious strategy for cancer treatment. However, the hyperthermia-induced heat shock response and low Fenton reaction efficiency limited its clinical application. Here, we present self-assembled querce-tin-Fe3+ nanoparticles (Qu-Fe NPs) for synergetic near-infrared (NIR) light-triggered low-temperature PTT (LTPTT) and glutathione (GSH)-activated CDT. Qu-Fe NPs had a broad absorption range extending to the NIR region and excellent photothermal conversion ability. After endocytosis into cancer cells, these NPs partially released Qu that downregulated the expression of heat shock protein 70, in turn allowing for LTPTT. Moreover, Qu-Fe NPs could deplete the overexpressed GSH in cancer cells, increasing their sensitivity to reactive oxygen species. Meanwhile, Fe3+ could be reduced to Fe2+, which can react with endogenous H2O2 to generate hydroxyl radicals to achieve CDT. Heat generated by PTT could further accelerate the Fenton reaction in CDT, thus resulting in the synergistic effects between LTPTT and CDT. Both in vitro and in vivo results showed that Qu-Fe NPs could effectively inhibit tumor growth. This work presents a new approach for achieving mutually reinforced, synergetic NPs that can be used for LTPTT/CDT combination therapy.

摘要

光热疗法(PTT)与化学动力疗法(CDT)相结合是一种有效的癌症 治疗策略. 然而, 高温诱导的热休克反应和低Fenton反应效率限制了其 临床应用. 在这里, 我们提出了自组装槲皮素-Fe3+纳米颗粒(Qu-Fe NPs)用于协同近红外(NIR)光触发低温PTT (LTPTT)和谷胱甘肽(GSH) 激活CDT. Qu-Fe NPs具有较宽的吸收范围, 可延伸至近红外区域, 光热 转换能力良好. 这些NPs在进入癌细胞后, 释放出来的Qu可下调HSP70 的表达, 以实现LTPTT. 此外, Qu-Fe NPs可以消耗癌细胞中的GSH, 增 加癌细胞对活性氧的敏感性. 同时, Fe3+可以被还原为Fe2+, 与内源性 H2O2反应生成羟基自由基, 实现CDT. PTT产生的热量可以进一步加速 CDT中的Fenton反应, 从而导致LTPTT与CDT之间的协同效应. 实验结 果表明, Qu-Fe NPs能有效抑制肿瘤生长. 这项工作提出了一种新的方 法来实现LTPTT/CDT的联合治疗.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (62175262), the Science and Technology Innovation Program of Hunan Province (2022RC1201), the Fundamental Research Fund for the Central South Universities (2020CX021), the Key R & D plan of Hunan Province (2022SK2101), and the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China

    Tangna Pan  (潘唐纳), E. Pang  (庞娥), Shaojing Zhao  (赵少静), Xuejian Xing  (邢雪建), Qiuxia Tan  (谭秋霞), Qin Wang  (王琴) & Minhuan Lan  (蓝敏焕)

  2. Testing Technology Company of Changsha Research Institute of Mining and Metallurgy Co., LTD, Changsha, 410012, China

    Ke Yang  (杨柯)

  3. Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China

    Jiwei Li  (李基炜)

  4. Department of Breast and Thyroid Gland Surgical, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China

    Jianing Yi  (易嘉宁)

Authors
  1. Tangna Pan  (潘唐纳)
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  2. Ke Yang  (杨柯)
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  3. Jiwei Li  (李基炜)
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  10. Minhuan Lan  (蓝敏焕)
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Contributions

Lan M planed and supervised the project. Pan T, Yang K and Li J conceived the study, wrote the paper, and drafted the figures and tables. Pang E, Xing X, Tan Q and Wang Q contributed to cell and animal experiments. Zhao S and Yi J contributed to data analysis and polished the article. The authors read and approved the final manuscript.

Corresponding authors

Correspondence to Jianing Yi  (易嘉宁) or Minhuan Lan  (蓝敏焕).

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The authors declare that they have no conflict of interest.

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Supporting data are available in the online version of the paper.

Minhuan Lan received his PhD degree in organic chemistry in 2013 from the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (TIPC, CAS). Then, he joined Prof. Wenjun Zhang’s group as a postdoctoral researcher at the City University of Hong Kong (from 2013 to 2017). He joined Central South University (CSU) in 2017. Now, he is a professor at CSU, and his current research interests include the design and development of fluorescent materials and investigation of their applications in biosensing, bioimaging, and phototherapy.

Jianing Yi received his BS degree from Hunan Normal University in 2017. He entered the MS course at Hunan Normal University in 2018, majored in medicine and received his MS degree in 2021. Then he joined Hunan Provincial People’s Hospital, The Affiliated First Hospital of Hunan Normal University in 2021. Now, he is engaged in the development and application of nanomaterials in cancer.

Tangna Pan is studying for her Master’s degree at the College of Chemistry and Chemical Engineering, CSU. Her research interest focuses on cancer phototherapy.

Ke Yang received her Master’s degree in organic chemistry in 2022 from CSU under the supervision of Prof. Minhuan Lan. Now, she is a PhD candidate at RWTH Aachen University, Leibniz institute for interactive materials.

Jiwei Li received his PhD degree from Fudan University Shanghai Cancer Center under the supervision of Prof. Xiaoyan Zhou in 2021. Then, he joined the Second Xiangya Hospital, CSU in 2021. Now, he is a research assistant at CSU and his research interests include cancer biology and cancer treatment.

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Self-assembled quercetin-Fe3+ nanoparticles for synergetic near-infrared light-triggered low-temperature photothermal/glutathione-activated chemodynamic therapy

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Pan, T., Yang, K., Li, J. et al. Self-assembled quercetin-Fe3+ nanoparticles for synergetic near-infrared light-triggered low-temperature photothermal/glutathione-activated chemodynamic therapy. Sci. China Mater. 66, 3735–3743 (2023). https://doi.org/10.1007/s40843-023-2536-1

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