Skip to main content
SpringerLink
Log in

An Effective Viscosupplementation Strategy for Treating Knee Joint: Preliminary Outcome from the In Vitro Study

  • Published:
Journal of Bio- and Tribo-Corrosion Aims and scope Submit manuscript

Abstract

To treat the knee joint disorder problem with less cost, viscosupplementation was introduced. However, the presence of poor adsorption properties in viscosupplementation might affect the pain relief percentage. Also, the key drawback of viscosupplementation is its inconsistency and fluctuating result in healing knee joint problem that tends to action disability. To address these issues, a novel Albumin blended Hyaluronic Acid (AbHA)-based viscosupplementation experimental work was prepared for treating knee joint problems. Here, the combination of Albumin and Hydraulic Acid is prepared and mixed thoroughly in an ultrasonic mixer. Here, the maximum possible content of albumin is equipped in the first sample, average content is equipped in the second sample, the minimum possible amount of albumin is prepared as the third sample, and the substance HA is utilized as general synovial fluid; the obtained proportions of HA and albumin ratios are 6:2.100, 6:0.480, and 6:0.075, respectively. Subsequently, a bovine plug is a stainless steel that is applied in the knee joint, and the pin-on-the-disk apparatus is utilized to test the wear rate and High-Frequency Reciprocating Test Rig. Finally, the rheological properties of the prepared sample are tested in the Anton par rheometer. Hereafter, tribological characteristics are measured and have attained the diminished wear as 13.51% and a low coefficient score of 0.02 for the proposed model. Also, the standard variation gained by the developed model is 4.3, which is less compared to other methods such as Anteromedial injection of HA, and in situ HA viscosupplement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. Siddaiah A, Menezes PL (2016) Advances in bio-inspired tribology for engineering applications. J Bio Tribo-Corros 2(4):23. https://doi.org/10.1007/s40735-016-0053-0

    Article  Google Scholar 

  2. Patil A, Jebaseelan DD (2020) Tribology, characterization, and surface roughness study of a CAD/CAM-fabricated zirconia. J Bio Tribo-Corros 6(2):32. https://doi.org/10.1007/s40735-020-0327-4

    Article  Google Scholar 

  3. Manoj A, Kasar AK, Menezes PL (2019) Tribocorrosion of porous titanium used in biomedical applications. J Bio Tribo-Corros 5(1):3. https://doi.org/10.1007/s40735-018-0194-4

    Article  Google Scholar 

  4. De Lucia O, Murgo A, Pregnolato F, Pontikaki I, De Souza M, Sinelli A (2020) Hyaluronic acid injections in the treatment of osteoarthritis secondary to primary inflammatory rheumatic diseases: a systematic review and qualitative synthesis. Adv Ther. https://doi.org/10.1007/s12325-020-01256-7

    Article  Google Scholar 

  5. Van Dijk CN (2018) But it does work (and we know that it does)…. JISACOS 3(5):249–250. https://doi.org/10.1136/jisakos-2018-000254

    Article  Google Scholar 

  6. Prekasan D, Saju KK (2019) Tribological effectiveness of viscosupplements for osteoarthritis in the knee joint. SN Appl Sci 1(9):1018. https://doi.org/10.1007/s42452-019-1030-2

    Article  CAS  Google Scholar 

  7. Gusho CA, Jenson M (2019) Patient-reported outcomes of short-term intra-articular hyaluronic acid for osteoarthritis of the knee: a consecutive case series study subjects. Cureus. https://doi.org/10.7759/cureus.4972

    Article  Google Scholar 

  8. Jevsevar DS, Manner PA, Bozic KJ, Goldberg MJ, Martin WR, Cummins DS (2013) The American Academy of Orthopaedic Surgeons evidence-based guideline on treatment of osteoarthritis of the knee, 2nd edition. J Bone Joint Surg Am 95(20):1885–1886.

  9. Maheu E, Bannuru RR, Herrero-Beaumont G, Allali F (2019) Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: results of an extensive critical literature review. Semin Arthritis Rheumatism. https://doi.org/10.1016/j.semarthrit.2018.06.002

    Article  Google Scholar 

  10. Heeckt P, Dasa V, Lim S (2019) Real-world evidence for safety and effectiveness of repeated courses of hyaluronic acid injections on the time to knee replacement surgery. Am J Orthop 47(7):1–17. https://doi.org/10.12788/ajo.2018.0058

    Article  Google Scholar 

  11. Wallace IJ, Worthington S, Felson DT, Jurmain RD, Wren KT, Maijanen H (2017) Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci USA 114(35):9332–9336. https://doi.org/10.1073/pnas.1703856114

    Article  CAS  Google Scholar 

  12. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G (2010) Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev (2):CD005321

  13. Trigkilidas D, Anand A (2013) The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain. Ann R Coll Surg Engl 95(8):545–551. https://doi.org/10.1308/rcsann.2013.95.8.545

    Article  CAS  Google Scholar 

  14. Askari A, Gholami T, Naghizadeh MM, Farjam M (2016) Hyaluronic acid compared with corticosteroid injections for the treatment of osteoarthritis of the knee : a randomized control trial. Springerplus 5(1):442. https://doi.org/10.1186/s40064-016-2020-0

    Article  CAS  Google Scholar 

  15. Connell JXO (2000) Pathology of the Synovium. Am J Clin Pathol 114(5):773–784

    Article  Google Scholar 

  16. Rebenda D, Vrbka M, Hartl M (2018) Effect of hyaluronic acid on the friction of articular cartilage. Conf Mech 24:709–712

    Google Scholar 

  17. Lois M, Las B, Moss M (2000) Oxidant-antioxidant balance in acute lung injury. Chest 122(6):314S-320S. https://doi.org/10.1378/chest.122.6_suppl.314S

    Article  Google Scholar 

  18. Brignardello-Petersen R, Guyatt GH, Buchbinder R, Poolman RW, Schandelmaier S, Chang Y (2017) Knee arthroscopy versus conservative management in patients with degenerative knee disease : a systematic review. BMJ Open. https://doi.org/10.1136/bmjopen-2017-016114

    Article  Google Scholar 

  19. Estades-rubio FJ, Reyes-mart A, Morales-marcos V (2017) Knee viscosupplementation: cost-effectiveness analysis between stabilized hyaluronic acid in a single injection versus five injections of standard hyaluronic acid. Int J Mol Sci 18(658):1–9. https://doi.org/10.3390/ijms18030658

    Article  Google Scholar 

  20. Goncars V, Jakobsons E, Blums K, Briede I, Patetko L (2017) The comparison of knee osteoarthritis treatment with hyaluronic acid injections. Medicina 53(2):101–108. https://doi.org/10.1016/j.medici.2017.02.002

    Article  Google Scholar 

  21. Balazs EA (1974) The physical properties of synovial fluid and the special role of hyaluronic acid. Disord Knee 2:61–74

    Google Scholar 

  22. Liang J (2008) Investigation of synthetic and natural lubricants. PhD Thesis, North Carolina State University

  23. Fam H, Bryant JT, Kontopoulou M (2007) Rheological properties of synovial fluids. Biorheology, IOS Press 44:59–74

    CAS  Google Scholar 

  24. Pendleton AMAE (2008) Biofluid lubrication for artificial joints. Doctoral dissertation, Texas A&M University

  25. Swann DA, Silver FH, Slayter HS, Stafford W, Shore E (1985) The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids. Biochem J 225(1):195–201. https://doi.org/10.1042/bj2250195

    Article  CAS  Google Scholar 

  26. Schmid T, Lindley K et al (2002) Superficial zone protein (SZP) is an abundant glycoprotein in human synovial fluid and serum. In: The many faces of osteoarthritis. Birkhäuser Basel, Boston, pp 159–161. https://doi.org/10.1007/978-3-0348-8133-3_16

  27. Irwin RM, Feeney E, Secchieri C, Galesso D (2020) Distinct tribologicalendotypes of pathological human synovial fluid reveal characteristic biomarkers and variation in efficacy of viscosupplementation at reducing local strains in articular cartilage. Osteoarthr Cartil. https://doi.org/10.1016/j.joca.2020.02.029

    Article  Google Scholar 

  28. Xiao J, Hu Y, Huang L, Huang ZF, Jiang WZ (2020) Injection route affects intra-articular hyaluronic acid distribution and clinical outcome in viscosupplementation treatment for knee osteoarthritis: a combined cadaver study and randomized clinical trial. Drug Deliv Transl Res. https://doi.org/10.1007/s13346-020-00793-6

    Article  Google Scholar 

  29. Storozhylova N, Crecente-Campo J et al (2020) An in situ hyaluronic acid-fibrin hydrogel containing drug-loaded nanocapsules for intra-articular treatment of inflammatory joint diseases. Regen Eng Transl Med 6(2):201–216. https://doi.org/10.1007/s40883-020-00154-2

    Article  CAS  Google Scholar 

  30. Vaquero-Picado A, Rodríguez-Merchán EC (2020) Intra-articular injections of corticosteroids and hyaluronic acid in knee osteoarthritis. In: Comprehensive treatment of knee osteoarthritis. Springer, Cham, pp 25–29. https://doi.org/10.1007/978-3-030-44492-1_3

  31. Martin RB, Burr DB, Sharkey AN, David F (2015) Synovial joint mechanics. Springer, New York

    Book  Google Scholar 

  32. Mazzucco D, Scott R, Spector M (2004) Composition of joint fluid in patients undergoing total knee replacement and revision arthroplasty: correlation with flow properties. Biomaterials 25(18):4433–4445. https://doi.org/10.1016/j.biomaterials.2003.11.023

    Article  CAS  Google Scholar 

  33. Schwarz IM, Hills BA (1998) Surface active phospholipids as the lubricating component of lubricin. Br J Rheumatol 37(1):21–26. https://doi.org/10.1093/rheumatology/37.1.21

    Article  CAS  Google Scholar 

  34. Saranraj P (2017) Hyaluronic acid production and its applications—a review. Int J Pharm Biol Arch. https://doi.org/10.22377/IJPBA.V4I5.1126

  35. Chen WY, Marcellin E, Hung J, Nielsen LK (2009) Hyaluronan molecular weight is controlled by UDP-N-acetylglucosamine concentration in Streptococcus zooepidemicus. J Biol Chem 284(27):18007–18014. https://doi.org/10.1074/jbc.M109.011999

    Article  CAS  Google Scholar 

  36. Ogston BYAG, Stanier JE (1953) The physiological function of hyaluronic acid in synovial fluid; viscous, elastic and lubricant properties. Biochemistry 199(2–3):244–252. https://doi.org/10.1113/jphysiol.1953.sp004842

    Article  Google Scholar 

  37. Wu SC, Huang PY, Wu C, Chang J (2018) Hyaluronan microenvironment enhances cartilage regeneration of human adipose-derived stem cells in a chondral defect model. Int J Biol Macromol 119:726–740. https://doi.org/10.1016/j.ijbiomac.2018.07.054

    Article  CAS  Google Scholar 

  38. Quinlan GJ, Martin GS, Evans TW (2005) Albumin: biochemical properties and therapeutic potential. Hepatology 41(6):1211–1219

    Article  CAS  Google Scholar 

  39. Avenoso A, Ascola AD, Scuruchi M, Mandra G, Calatroni A, Saitta A (2017) Hyaluronan in experimental injured/inflamed cartilage: in vivo studies. Life Sci 193:132–140. https://doi.org/10.1016/j.lfs.2017.11.006

    Article  CAS  Google Scholar 

  40. Nečas D, Sadecká K, Vrbka M et al (2019) Observation of lubrication mechanisms in knee replacement: a pilot study. Biotribology 17:1–7. https://doi.org/10.1016/j.biotri.2019.02.001

    Article  Google Scholar 

  41. Drescher P, Oldorf P, Dreier T et al (2020) Ring-shaped surface microstructures for improved lubrication performance of joint prostheses. Lubricants 8(4):45. https://doi.org/10.3390/lubricants8040045

    Article  Google Scholar 

  42. Wan H, Ren K, Kaper HJ, Sharma PK (2020) Abioinspiredmucoadhesive restores lubrication of degraded cartilage through reestablishment of lamina splendens. Colloids Surf B 193:110977. https://doi.org/10.1016/j.colsurfb.2020.110977

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Mechanical Engineering, School of Engineering, Kochi, Kerala, 682022, India

    D. Prekasan & K. K. Saju

Authors
  1. D. Prekasan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. K. Saju
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. Prekasan.

Ethics declarations

Conflict of interest

The authors declare that they have no potential conflict of interest.

Ethical Approval

All applicable institutional and/or national guidelines for the care and use of animals were followed.

Informed Consent

For this type of study formal consent is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Prekasan, D., Saju, K.K. An Effective Viscosupplementation Strategy for Treating Knee Joint: Preliminary Outcome from the In Vitro Study. J Bio Tribo Corros 8, 9 (2022). https://doi.org/10.1007/s40735-021-00603-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s40735-021-00603-7

Keywords

Search

Navigation