Healthcare provision for insect venom allergy patients during the COVID-19 pandemic

The population prevalence of insect venom allergy ranges between 3–5%, and it can lead to potentially life-threatening allergic reactions. Patients who have experienced a systemic allergic reaction following an insect sting should be referred to an allergy specialist for diagnosis and treatment. Due to the widespread reduction in outpatient and inpatient care capacities in recent months as a result of the COVID-19 pandemic, the various allergy specialized centers in Germany, Austria, and Switzerland have taken different measures to ensure that patients with insect venom allergy will continue to receive optimal allergy care. A recent data analysis from the various centers revealed that there has been a major reduction in newly initiated insect venom immunotherapy (a 48.5% decline from March–June 2019 compared to March–June 2020: data from various centers in Germany, Austria, and Switzerland). The present article proposes defined organizational measures (e.g., telephone and video appointments, rearranging waiting areas and implementing hygiene measures and social distancing rules at stable patient numbers) and medical measures (collaboration with practice-based physicians with regard to primary diagnostics, rapid COVID-19 testing, continuing already-initiated insect venom immunotherapy in the outpatient setting by making use of the maximal permitted injection intervals, prompt initiation of insect venom immunotherapy during the summer season, and, where necessary, using outpatient regimens particularly out of season) for the care of insect venom allergy patients during the COVID-19 pandemic.


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Abstract The population prevalence of insect venom allergy ranges between 3-5%, and it can lead to potentially life-threatening allergic reactions. Patients who have experienced a systemic allergic reaction following an insect sting should be referred to an allergy specialist for diagnosis and treatment. Due to the widespread reduction in outpatient and inpatient care capacities in recent months as a result of the COVID-19 pandemic, the various allergy specialized centers in Germany, Austria, and Switzerland have taken different measures to ensure that patients with insect venom allergy will continue to receive optimal allergy care. A recent data analysis from the various centers revealed that there has been a major reduction in newly initiated insect venom immunotherapy (a 48.5% decline from March-June 2019 compared to March-June 2020: data from various centers in Germany, Austria, and Switzerland). The present article proposes defined organizational measures (e.g., telephone and video appointments, rearranging waiting areas and implementing hygiene measures and social distancing rules at stable patient numbers) and medical measures (collaboration with practice-based physicians with regard to primary diagnostics, rapid COVID-19 testing, continuing already-initiated insect venom immunotherapy in the outpatient setting by making use of the maximal permitted injection intervals, prompt initiation of insect venom immunotherapy during the summer season, and, where necessary, using outpatient regimens particularly out of season) Keywords Venom · Allergy · Immunotherapy · SARS-Co-2 · Lockdown

History of a systemic reacƟon in temporal relaƟon
At a population prevalence of 3-5%, insect venom allergy is common and can potentially trigger lifethreatening allergic reactions [1]. Therefore, patients who have experienced a systemic allergic reaction to an insect sting should be referred to an allergy specialist for diagnosis and treatment. In addition to patient history taking, where the symptoms and concomitant circumstances of the reaction are recorded, the standard procedure includes titrated skin prick testing and, if necessary, intracutaneous testing and/or determination of specific immunoglobulin (Ig)-E antibodies to insect venom and, where appropriate, their components to identify immediate-type allergy ( Fig. 1). For a better risk assessment, especially after the onset of severe reactions, the determination of basal serum tryptase is also recommended. If the above-mentioned findings are positive and the patient has a clear history of a systemic allergic reaction in the context of a venom sting, the initiation of allergen-specific immunotherapy with the relevant insect venom is recommended [2]. The failure to initiate specific immunotherapy in at-risk patients in a timely manner, leads to an increase of their health risks and may result in an in- creased need of emergency care for insect sting reactions. Such situations should be avoided during possible healthcare shortage. The significance of the COVID-19 pandemic for allergology has recently been discussed in a number of position papers [3,4]. Due to the widespread reduction in outpatient and inpatient care capacities in recent months as a result of the COVID-19 pandemic, the various allergy specialists from Germany, Austria, and Switzerland have taken different measures to ensure that patients with insect venom allergy continue to receive optimal allergy care. However, overall, there has been a large reduction in newly initiated insect venom immunotherapy (Table 1) during the lock down. A survey among large allergy centers with regard to newly initiated venom immunotherapy (VIT) revealed an almost 50% reduction for the months March-June 2020 compared to the similar period in 2019 (Fig. 2). This decline was related to reduced hospital capacities, but also the fact that patients considered to visit a physician or a hospital as a high-risk due to the COVID-19 pandemic. Thus, the authors propose measures to ensure allergy care for insect venom-allergic individuals during times of emergency regulations in the healthcare system, such as during the COVID-19 pandemic (Table 2). In the case of shortages, triage according to the severity of the sting reaction Adapting departmental organization, e.g., collaboration with other departments, extended outpatient clinic times, up-titration at weekends sIgE specific Immunoglobin E

Continuation of already-initiated insect venom immunotherapy
Allergen-specific immunotherapy with insect venom that has already been initiated should be continued as consistently as possible, despite eventual limitations in medical resources, by making use of the permissible length of intervals (see also [3]). Interrupting specific immunotherapy can cause a loss of protection and leads to unnecessary expense at a later point as a result of having to re-start therapy if the treatment interval has been exceeded. If the patient has COVID-19 themselves, a pause in treatment is recommended until recovery. Following recovery, the dose should be re-up-titrated (if still within the permitted interval) or allergen-specific immunotherapy newly initiated if necessary. In some cases, it may be beneficial to contact the patient by telephone or telehealth appointment prior to their personal visit for the immunotherapy injection in order to rule out current contraindications to the injection, thereby potentially saving the patient an unnecessary visit.

New initiation of insect venom immunotherapy
It is possible to postpone the new initiation of insect venom immunotherapy out of season, assuming the time window is taken into account (see also [3]). Postponing initiation therapy during the summer season should be avoided, in order that the patient is not exposed to the risk of a repeat severe reaction to an accidental sting. Treatment initiation should preferably be performed as ultra-rush therapy under medical supervision. One-to five-day protocols have proven successful to this end [5,6]. They have the advantage that the maximum dose is achieved after a short initiation treatment phase. Shortened outpatient up-titration protocols have also been investigated for vespid venom allergy patients and show good results in terms of safety [7]. However, they require a longer initiation phase (7 weeks), implying that such treatment protocols should be preferred out of the season.
In summary, the diagnostic work-up of insect venom allergy, including the patient history and skin testing, should be adapted to the prevailing conditions. Initiation of immunotherapy should continue to be started with ultra-rush protocols and, above all, not postponed during the summer season. During the out-of-season period and in case of shortages of inpatient resources, or in case of certain regional requirements, an up-titration can be performed in an outpatient setting. A shortened, 7-week protocol for vespid venom allergy patients has been recently published [7]. Whenever possible, outpatient uptitration should be performed at a center experienced with this therapy and is able to provide emergency medical care. review fees from ALK-Abelló, Novartis, and Educational Institutions, outside the submitted work. In addition, Dr. Saloga has a patent Encapsulation of allergens issued. K. Schäkel declares that he received honoraria from ALK-Abelló during the course of and outside the present work. A. Trautmann declares that he received honoraria from ALK-Abelló during the course of the present work. R. Treudler declares that she received honoraria from ALK-Abelló during the course of the present work. Outside the present work, Treudler declares that she has received honoraria from ALK-Abelló, Novartis, Takeda, Gesundheitsnetz Leipzig, GEKA mbH, Sanofi, and AbbVie, as well as grants from Hautnetz Leipzig e. V.; she also declares a scientific collaboration with the Fraunhofer Institute. B. Wedi declares that she has received grants, lecture fees, and honoraria for advisory board participation, travel cost reimbursement for congresses, research grants, as well as financial support from Novartis. Wedi also declares that she has received research grants, lecture fees, honoraria for advisory board participation, travel cost reimbursement for congresses, and non-financial support from Shire, as well as lecture fees and honoraria for advisory board participation from ALK-Abéllo. Wedi has also received lecture fees from HAL-Allergy and Bencard, as well as honoraria from Sobi, all outside the present work. G. Sturm declares that he has received grants from ALK-Abelló, as well as honoraria from Novartis, Bencard, Stallergens, HAL, Allergopharma, and Mylan, outside the present work. F. Rueff declares that she has received grants from Novartis, consultancy fees from Bencard, LEO-Pharma, Novartis, and UCB, as well as lecture fees from Abbvie, ALK, Allergopharma, Bencard, HAL, MEDA Pharma, Mylan, Novartis, and UCB, outside the present work.
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